Sarissa Capital Management LP

Q4 2025 13F-HR Holdings

Location
Greenwich, CT
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
9
Total value ($000)
$222,909
Net value change ($000)
+42,517 (23.6%)
New positions
1
Sold out positions
0
Turnover %
2.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
IRWD 32,794 157.3%
BHVN 5,794 NEW
INVA 4,900 9.5%
AMRN 2,999 14.7%
LNTH 2,768 29.7%
REGN 878 37.3%
NBIX 440 1.0%
Top Reduces (Value $000, Stocks/ETFs)
CYTK -7,151 -22.1%
VOR -905 -73.2%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type