EcoR1 Capital, LLC

Q3 2025 13F-HR Holdings

Location
San Francisco, CA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
30
Total value ($000)
$2,083,869
Net value change ($000)
+394,538 (23.4%)
New positions
6
Sold out positions
12
Turnover %
15.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
QURE 177,230 318.7%
ZYME 104,056 36.1%
ANAB 66,350 37.9%
ORIC 64,314 391.6%
CRNX 55,274 44.8%
JAZZ 43,823 24.2%
TNGX 34,869 64.1%
BBOT 32,692 NEW
GLPG 28,725 99.0%
MBX 24,044 183.3%
Top Reduces (Value $000, Stocks/ETFs)
APLS -127,907 -62.1%
iTeos Therapeutics, Inc. -106,569 -100.0%
JANX -33,953 -100.0%
AKRO -23,478 -100.0%
VRNA -18,916 -100.0%
TECX -18,581 -100.0%
KURA -16,512 -68.1%
PCRX -10,934 -100.0%
VYGR -9,054 -74.3%
REPL -7,900 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type