BAKER BROS. ADVISORS LP

Q1 2023 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2023
Date filed
5/15/2023
Form type
13F-HR
Num holdings
105
Total value ($000)
$18,379,749
Net value change ($000)
+1,728,366 (10.4%)
New positions
7
Sold out positions
13
Turnover %
4.7%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/14/2023 Next filing: 8/14/2023 SEC filing

Snapshot: Change Analysis

Compared to Q4 2022
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
Seagen Inc. 3,469,936 57.6%
ACAD 121,860 18.3%
RVMD 53,005 1001.4%
BMEA 47,658 268.6%
SpringWorks Therapeutics, Inc. 31,118 78.3%
ROIV 29,531 515.7%
KYNB 27,183 123.4%
BPMC 15,012 NEW
KYMR 13,449 18.7%
ALLO 7,790 NEW
Top Reduces (Value $000, Stocks/ETFs)
ASND -605,136 -100.0%
BMRN -418,136 -53.0%
INCY -289,571 -10.0%
Horizon Therapeutics Public Ltd Co -110,355 -100.0%
MDGL -74,150 -16.5%
RYTM -69,117 -37.4%
ONC -51,460 -2.0%
REPL -43,677 -35.1%
BCRX -39,912 -27.4%
AKRO -39,173 -30.2%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type