BAKER BROS. ADVISORS LP

Q2 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
6/30/2025
Date filed
8/14/2025
Form type
13F-HR
Num holdings
89
Total value ($000)
$10,307,840
Net value change ($000)
+1,271,138 (14.1%)
New positions
12
Sold out positions
11
Turnover %
2.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2025 Next filing: 11/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q1 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
INSM 365,738 89.1%
SMMT 246,469 52.3%
INCY 232,313 12.5%
ACAD 213,080 29.9%
KYMR 126,159 76.9%
RVMD 63,886 22.8%
RYTM 57,278 19.3%
GPCR 45,773 731.3%
RARE 43,744 76.6%
GRAL 42,188 101.3%
Top Reduces (Value $000, Stocks/ETFs)
ONC -264,851 -11.1%
MDGL -56,021 -8.6%
EWTX -39,650 -29.3%
ARGX -25,209 -54.8%
CRSP -22,259 -100.0%
CNTA -17,647 -100.0%
BCYC -16,764 -18.1%
2seventy bio, Inc. -12,338 -100.0%
CADL -11,973 -86.9%
TRDA -11,289 -25.7%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type