BAKER BROS. ADVISORS LP

Q1 2026 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
84
Total value ($000)
$17,415,690
Net value change ($000)
+337,066 (2.0%)
New positions
7
Sold out positions
9
Turnover %
1.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/17/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
PRAX 232,842 70.1%
KOD 202,379 36.3%
RVMD 176,139 23.4%
CELC 113,987 14.4%
ALKERMES PLC 73,891 26.4%
INSM 66,098 5.8%
SMMT 53,495 8.4%
KYMR 47,442 7.0%
EWTX 43,960 26.9%
MIRM 41,199 NEW
Top Reduces (Value $000, Stocks/ETFs)
ACAD -190,891 -16.7%
INCY -142,920 -4.7%
MDGL -126,082 -10.1%
RYTM -112,482 -18.8%
RARE -63,772 -100.0%
ONC -60,185 -2.3%
IMCR -58,477 -72.5%
TERN -38,380 -100.0%
GPCR -30,584 -30.7%
BCYC -26,560 -34.5%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type