BAKER BROS. ADVISORS LP

Q1 2014 13F-HR Holdings

Location
New York, NY
Holdings as of
3/31/2014
Date filed
5/15/2014
Form type
13F-HR
Num holdings
108
Total value ($000)
$7,867,925
Net value change ($000)
+772,196 (10.9%)
New positions
20
Sold out positions
7
Turnover %
3.2%
Sector allocation + QoQ delta (equities-only)

Snapshot: Change Analysis

Compared to Q4 2013
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
*SYNAGEVA BIOPHARMA CORP 218,600 32.9%
INTERMUNE INC 142,542 6449.9%
Seagen Inc. 117,731 14.2%
INTERCEPT PHARMACEUTICALS, INC. 59,775 241.3%
INCY 44,140 5.9%
Acorda Therapeutics, Inc. 37,910 NEW
HRTX 30,153 NEW
ANACOR PHARMACEUTICALS INC 19,987 47.6%
DERMA SCIENCES INC 17,164 62.0%
AQUINOX PHARMACEUTICALS INC 15,427 NEW
Top Reduces (Value $000, Stocks/ETFs)
PHARMACYCLICS INC -46,608 -5.1%
GENOMIC HEALTH INC -39,910 -10.0%
XOMA -34,878 -22.5%
MEDIVATION -25,421 -100.0%
HALO -22,026 -23.3%
Arrowhead Pharma Inc -21,507 -64.1%
CERS -13,952 -25.6%
*AEGERION PHARMACEUTICALS INC -11,778 -33.2%
Infinity Pharmaceuticals Inc. -8,883 -100.0%
BMRN -8,116 -5.9%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type