SR ONE CAPITAL MANAGEMENT, LP

Q3 2025 13F-HR Holdings

Location
Wayne, PA
Holdings as of
9/30/2025
Date filed
11/12/2025
Form type
13F-HR
Num holdings
12
Total value ($000)
$691,412
Net value change ($000)
+230,036 (49.9%)
New positions
0
Sold out positions
1
Turnover %
0.4%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/12/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CRSP 81,111 159.0%
ZBIO 61,443 129.1%
ACLX 38,132 24.7%
MLYS 37,839 89.4%
DSGN 27,150 123.4%
ORIC 8,352 18.2%
ORKA 3,451 71.5%
ENGN 2,385 87.6%
ALMS 1,940 33.0%
NKTX 1,367 24.7%
Top Reduces (Value $000, Stocks/ETFs)
SPRY -29,695 -42.4%
KALA -2,851 -100.0%
OCS -590 -9.4%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type