TCG Crossover Management, LLC

Q3 2025 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
9/30/2025
Date filed
11/17/2025
Form type
13F-HR
Num holdings
40
Total value ($000)
$2,032,902
Net value change ($000)
+1,157,394 (132.2%)
New positions
11
Sold out positions
9
Turnover %
13.9%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ABVX 557,442 1203.1%
CGON 52,411 54.9%
COGT 47,618 95.2%
AMLX 46,753 122.7%
TRML 39,116 165.6%
LQDA 38,887 NEW
CNTA 38,075 100.2%
DNTH 38,000 135.8%
AGIO 34,220 147.6%
RAPT 29,110 222.4%
Top Reduces (Value $000, Stocks/ETFs)
CDTX -48,997 -100.0%
SLNO -15,604 -100.0%
Third Harmonic Bio, Inc. -10,401 -100.0%
ELVN -9,990 -100.0%
NKTR -6,891 -100.0%
KURA -4,242 -100.0%
SLN -1,851 -10.5%
JBIO -640 -100.0%
TRDA -538 -13.7%
CABA -132 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type