Palo Alto Investors LP

Q1 2026 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
51
Total value ($000)
$653,863
Net value change ($000)
-64,489 (-9.0%)
New positions
5
Sold out positions
3
Turnover %
4.3%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/17/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
MIRM 17,684 143.1%
CLDX 9,402 NEW
UTHR 8,893 31.4%
BCAX 5,923 117.9%
ANNX 4,363 36.5%
SNDX 3,513 21.0%
IOVA 2,858 14.7%
TVTX 2,616 61.8%
CYTK 2,122 NEW
ANAB 1,939 5.8%
Top Reduces (Value $000, Stocks/ETFs)
FOLD -58,035 -78.3%
INSM -17,284 -20.3%
GOSS -13,862 -100.0%
BIIB -6,509 -20.1%
DNLI -6,083 -57.5%
PTCT -5,872 -8.6%
BMRN -5,644 -12.7%
CMPX -5,587 -41.1%
EHTH -5,132 -72.8%
NVCR -2,839 -16.9%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type