5AM Venture Management, LLC

Q2 2026 13F-HR Holdings

Location
San Francisco, CA
Holdings as of
6/30/2026
Date filed
8/14/2026
Form type
13F-HR
Num holdings
16
Total value ($000)
$287,892
Net value change ($000)
-72,317 (-20.1%)
New positions
0
Sold out positions
4
Turnover %
31.3%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
MPLT 14,734 76.3%
ZNTL 9,909 107.3%
ARTV 7,672 50.6%
PHVS 5,049 22.4%
BHVN 4,744 75.9%
CLDX 2,730 17.3%
SLN 2,719 108.3%
TECX 2,102 11.2%
EYPT 1,480 10.9%
SKYE 762 12.8%
Top Reduces (Value $000, Stocks/ETFs)
ERAS -56,403 -100.0%
CNTA -23,075 -100.0%
TRDA -21,337 -41.7%
GHRS -8,052 -100.0%
TYRA -6,546 -16.6%
SRZN -4,249 -37.6%
RLYB -2,617 -100.0%
TARA -1,904 -26.7%
CAMP -235 -0.9%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type