Frazier Life Sciences Management, L.P.

Q2 2025 13F-HR Holdings

Location
Palo Alto, CA
Holdings as of
6/30/2025
Date filed
8/14/2025
Form type
13F-HR
Num holdings
49
Total value ($000)
$2,500,739
Net value change ($000)
+312,830 (14.3%)
New positions
8
Sold out positions
6
Turnover %
9.9%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2025 Next filing: 11/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q1 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
VRNA 100,515 45.8%
PHAT 56,169 88.6%
MIRM 39,684 13.0%
ZLAB 33,097 261.7%
BBIO 32,722 24.9%
AURA 31,926 NEW
MBX 24,121 54.6%
EOLS 22,431 NEW
AKRO 19,572 NEW
CYTK 18,328 NEW
Top Reduces (Value $000, Stocks/ETFs)
RYTM -35,954 -100.0%
SLNO -35,665 -100.0%
KRYS -29,493 -23.8%
NAMS -29,149 -8.8%
Merus N.V. -15,704 -100.0%
TARS -15,177 -21.1%
TRVI -8,413 -13.0%
ACAD -7,812 -100.0%
RCKT -7,197 -100.0%
IMTX -5,628 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type