Darwin Global Management, Ltd.

Q4 2025 13F-HR Holdings

Location
St. Helier, Y9
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
6
Total value ($000)
$4,939,420
Net value change ($000)
+1,341,555 (37.3%)
New positions
3
Sold out positions
2
Turnover %
19.8%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
INSM 746,477 25.8%
BLTE 486,915 NEW
ABVX 176,016 66.7%
CDTX 125,188 131.8%
WAVE LIFE SCIENCES LTD 125,168 NEW
CAPR 23,168 NEW
Top Reduces (Value $000, Stocks/ETFs)
UTHR -317,617 -100.0%
QURE -23,760 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type