Karyopharm Therapeutics Inc. - KPTI

Sector: Healthcare · Industry: Pharmaceutical Preparations

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Company profile

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Q1 2026 · Q4 2025

Value (USD)

Total reported value ($000)

$148.9M

QoQ value delta ($000)

+$78.16M (+110.42%)

Implied price effect (QoQ)

-22.98%

Total shares

26,310,654

QoQ shares delta

+16,680,560 (+173.21%)

Total shares held by funds (by quarter)

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Top 25 only Full list

Partial Q1 2026 data: 85 holders have filed so far. Prior holders are carried forward until their next 13F confirms a change.

Manager	Value ($000)	Shares	% of 13F
Ikarian Capital, LLC	14,334	2,573,435	1.16%
Commodore Capital LP	10,861	1,950,000	0.63%
RA CAPITAL MANAGEMENT, L.P.	10,679	1,917,354	0.11%
ADAGE CAPITAL PARTNERS GP, L.L.C.	10,061	1,806,322	0.02%
T. Rowe Price Investment Management, Inc.	8,590	1,542,090	0.01%
SUSQUEHANNA INTERNATIONAL GROUP, LLP	7,324	1,315,038	0.0%
Caption Management, LLC	6,583	1,181,900	0.04%
GOLDMAN SACHS GROUP INC	5,278	947,579	0.0%
Catalio Capital Management, LP	5,000	897,709	1.04%
BOOTHBAY FUND MANAGEMENT, LLC	4,179	750,410	0.05%
Squadron Capital Management LLC	4,177	750,000	1.53%
VANGUARD CAPITAL MANAGEMENT LLC	4,120	739,745	0.0%
VANGUARD GROUP INC	4,118	559,619	0.0%
Avidity Partners Management LP	3,853	463,741	0.87%
JANE STREET GROUP, LLC	3,306	593,701	0.0%
MILLENNIUM MANAGEMENT LLC	2,849	511,571	0.0%
CITADEL ADVISORS LLC	2,826	507,500	0.0%
Affinity Asset Advisors, LLC	2,785	500,000	0.14%
Soleus Capital Management, L.P.	2,450	440,000	0.1%
ADAR1 Capital Management, LLC	1,904	341,936	0.11%
GROUP ONE TRADING LLC	1,895	340,227	0.0%
Boxer Capital Management, LLC	1,685	302,536	0.22%
DAVIDSON KEMPNER CAPITAL MANAGEMENT LP	1,671	300,000	0.02%
Eversept Partners, LP	1,670	299,974	0.09%
ACORN CAPITAL ADVISORS, LLC	1,603	287,826	0.46%