423494103
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | History | New | 7,808,627 | 286,810 | 2.49% | — | 1 | +7,808,627 | New | Q2 2026 | Aug 14, 2026 |
| Novo Holdings A/S | History | New | 4,180,550 | 153,551 | 8.92% | — | 2 | +4,180,550 | New | Q2 2026 | Aug 14, 2026 |
| FMR LLC | History | New | 3,697,837 | 135,821 | 0.01% | — | 3 | +3,697,837 | New | Q2 2026 | Aug 13, 2026 |
| Capital International Investors | History | New | 3,603,876 | 132,370 | 0.03% | — | 4 | +3,603,876 | New | Q2 2026 | Aug 12, 2026 |
| Deep Track Capital, LP | History | New | 3,602,093 | 132,304 | 1.93% | — | 5 | +3,602,093 | New | Q2 2026 | Aug 14, 2026 |
| Siren, L.L.C. | History | New | 2,086,834 | 76,649 | 1.55% | — | 6 | +2,086,834 | New | Q2 2026 | Aug 13, 2026 |
| Avoro Capital Advisors LLC | History | New | 1,925,150 | 70,710 | 0.63% | — | 7 | +1,925,150 | New | Q2 2026 | Aug 14, 2026 |
| Bain Capital Life Sciences Investors, LLC | History | New | 1,650,000 | 60,604 | 3.6% | — | 8 | +1,650,000 | New | Q2 2026 | Aug 14, 2026 |
| JPMORGAN CHASE & CO | History | New | 1,152,420 | 42,328 | 0.0% | — | 9 | +1,152,420 | New | Q2 2026 | Aug 12, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | New | 780,758 | 28,677 | 0.0% | — | 10 | +780,758 | New | Q2 2026 | Aug 13, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | New | 746,040 | 27,404 | 0.0% | — | 11 | +746,040 | New | Q2 2026 | Aug 14, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | History | New | 715,791 | 26,291 | 0.15% | — | 12 | +715,791 | New | Q2 2026 | Aug 14, 2026 |
| Rock Springs Capital Management LP | History | New | 575,432 | 21,135 | 1.03% | — | 13 | +575,432 | New | Q2 2026 | Aug 14, 2026 |
| Bellevue Group AG | History | New | 550,000 | 20,201 | 0.43% | — | 14 | +550,000 | New | Q2 2026 | Aug 14, 2026 |
| CITADEL ADVISORS LLC | History | New | 523,450 | 19,226 | 0.0% | — | 15 | +523,450 | New | Q2 2026 | Sep 02, 2026 |
| BlackRock, Inc. | History | New | 283,833 | 10,425 | 0.0% | — | 16 | +283,833 | New | Q2 2026 | Aug 07, 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | History | New | 275,000 | 10,100 | 0.11% | — | 17 | +275,000 | New | Q2 2026 | Aug 14, 2026 |
| ExodusPoint Capital Management, LP | History | New | 218,287 | 8,017 | 0.05% | — | 18 | +218,287 | New | Q2 2026 | Aug 14, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | New | 211,798 | 7,783 | 0.0% | — | 19 | +211,798 | New | Q2 2026 | Aug 12, 2026 |
| BRAIDWELL LP | History | New | 160,000 | 5,876 | 0.22% | — | 20 | +160,000 | New | Q2 2026 | Aug 14, 2026 |
| MARSHALL WACE, LLP | History | New | 154,674 | 5,681 | 0.0% | — | 21 | +154,674 | New | Q2 2026 | Aug 13, 2026 |
| Woodline Partners LP | History | New | 150,040 | 5,510 | 0.02% | — | 22 | +150,040 | New | Q2 2026 | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | History | New | 138,030 | 5,069 | 0.23% | — | 23 | +138,030 | New | Q2 2026 | Aug 13, 2026 |
| Ensign Peak Advisors, Inc | History | New | 115,394 | 4,238 | 0.01% | — | 24 | +115,394 | New | Q2 2026 | Aug 14, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | New | 112,499 | 4,132 | 0.0% | — | 25 | +112,499 | New | Q2 2026 | Aug 13, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | New | 108,236 | 3,975 | 0.0% | — | 26 | +108,236 | New | Q2 2026 | Aug 14, 2026 |
| AMERIPRISE FINANCIAL INC | History | New | 81,928 | 3,009 | 0.0% | — | 27 | +81,928 | New | Q2 2026 | Aug 14, 2026 |
| STATE STREET CORP | History | New | 76,900 | 2,824 | 0.0% | — | 28 | +76,900 | New | Q2 2026 | Sep 22, 2026 |
| Burkehill Global Management, LP | History | New | 75,000 | 2,754 | 0.1% | — | 29 | +75,000 | New | Q2 2026 | Aug 14, 2026 |
| Aberdeen Group plc | History | New | 52,117 | 1,914 | 0.0% | — | 30 | +52,117 | New | Q2 2026 | Jul 31, 2026 |
| Opaleye Management Inc. | History | New | 47,652 | 1,750 | 0.16% | — | 31 | +47,652 | New | Q2 2026 | Aug 14, 2026 |
| UBS Group AG | History | New | 47,351 | 1,739 | 0.0% | — | 32 | +47,351 | New | Q2 2026 | Aug 13, 2026 |
| Parkman Healthcare Partners LLC | History | New | 45,000 | 1,652 | 0.17% | — | 33 | +45,000 | New | Q2 2026 | Aug 14, 2026 |
| NORTHERN TRUST CORP | History | New | 40,487 | 1,487 | 0.0% | — | 34 | +40,487 | New | Q2 2026 | Aug 13, 2026 |
| Ghisallo Capital Management LLC | History | New | 40,000 | 1,469 | 0.03% | — | 35 | +40,000 | New | Q2 2026 | Aug 14, 2026 |
| TD ASSET MANAGEMENT INC | History | New | 33,098 | 1,215 | 0.0% | — | 36 | +33,098 | New | Q2 2026 | Aug 04, 2026 |
| SEVEN GRAND MANAGERS, LLC | History | New | 30,000 | 1,101 | 0.04% | — | 37 | +30,000 | New | Q2 2026 | Aug 14, 2026 |
| SOROS FUND MANAGEMENT LLC | History | New | 25,000 | 918 | 0.01% | — | 38 | +25,000 | New | Q2 2026 | Aug 14, 2026 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | History | New | 18,720 | 687 | 0.0% | — | 39 | +18,720 | New | Q2 2026 | Sep 09, 2026 |
| GSA CAPITAL PARTNERS LLP | History | New | 17,661 | 649 | 0.04% | — | 40 | +17,661 | New | Q2 2026 | Aug 06, 2026 |
| XTX Topco Ltd | History | New | 17,389 | 638 | 0.01% | — | 41 | +17,389 | New | Q2 2026 | Aug 14, 2026 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | History | New | 13,183 | 484 | 0.03% | — | 42 | +13,183 | New | Q2 2026 | Aug 11, 2026 |
| Hudson Bay Capital Management LP | History | New | 12,202 | 448 | 0.0% | — | 43 | +12,202 | New | Q2 2026 | Aug 14, 2026 |
| Schonfeld Strategic Advisors LLC | History | New | 10,813 | 397 | 0.0% | — | 44 | +10,813 | New | Q2 2026 | Aug 14, 2026 |
| Weiss Asset Management LP | History | New | 10,000 | 367 | 0.0% | — | 45 | +10,000 | New | Q2 2026 | Aug 14, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | History | New | 8,169 | 300 | 0.0% | — | 46 | +8,169 | New | Q2 2026 | Aug 13, 2026 |
| Vanguard Global Advisers, LLC | History | New | 7,616 | 279 | 0.0% | — | 47 | +7,616 | New | Q2 2026 | Aug 13, 2026 |
| Squarepoint Ops LLC | History | New | 6,252 | 229 | 0.0% | — | 48 | +6,252 | New | Q2 2026 | Aug 14, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | New | 5,680 | 208 | 0.0% | — | 49 | +5,680 | New | Q2 2026 | Aug 14, 2026 |
| MORGAN STANLEY | History | New | 4,078 | 149 | 0.0% | — | 50 | +4,078 | New | Q2 2026 | Aug 13, 2026 |
| China Universal Asset Management Co., Ltd. | History | New | 3,600 | 132 | 0.01% | — | 51 | +3,600 | New | Q2 2026 | Jul 24, 2026 |
| CITIGROUP INC | History | New | 2,095 | 76 | 0.0% | — | 52 | +2,095 | New | Q2 2026 | Aug 03, 2026 |
| BARCLAYS PLC | History | New | 1,011 | 37 | 0.0% | — | 53 | +1,011 | New | Q2 2026 | Aug 14, 2026 |
| ROYAL BANK OF CANADA | History | New | 248 | 9 | 0.0% | — | 54 | +248 | New | Q2 2026 | Aug 14, 2026 |
| JONES FINANCIAL COMPANIES LLLP | History | New | 3 | 0 | — | — | — | +3 | New | Q2 2026 | Aug 14, 2026 |
| Tower Research Capital LLC (TRC) | History | New | 1 | 0 | — | — | — | +1 | New | Q2 2026 | Aug 11, 2026 |