423494103
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | History | No change | 7,808,627 | 286,810 | 2.49% | 2.49% | 1 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Novo Holdings A/S | History | No change | 4,180,550 | 153,551 | 8.92% | 8.92% | 2 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Capital International Investors | History | No change | 3,603,876 | 132,370 | 0.03% | 0.03% | 3 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| Deep Track Capital, LP | History | No change | 3,602,093 | 132,304 | 1.93% | 1.93% | 4 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| FMR LLC | History | Added to | 3,722,599 | 114,804 | 0.0% | 0.01% | 5 | +24,762 | 0.67% | Q3 2026 | Nov 10, 2026 |
| Siren, L.L.C. | History | No change | 2,086,834 | 76,649 | 1.55% | 1.55% | 6 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Avoro Capital Advisors LLC | History | No change | 1,925,150 | 70,710 | 0.63% | 0.63% | 7 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Bain Capital Life Sciences Investors, LLC | History | No change | 1,650,000 | 60,604 | 3.6% | 3.6% | 8 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| JPMORGAN CHASE & CO | History | Reduced | 932,857 | 30,411 | 0.0% | 0.0% | 9 | -219,563 | -19.05% | Q3 2026 | Nov 12, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | No change | 780,758 | 28,677 | 0.0% | 0.0% | 10 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| STATE STREET CORP | History | Added to | 927,245 | 28,596 | 0.0% | 0.0% | 11 | +850,345 | 1105.78% | Q3 2026 | Nov 12, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | No change | 746,040 | 27,404 | 0.0% | 0.0% | 12 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | History | No change | 715,791 | 26,291 | 0.15% | 0.15% | 13 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Rock Springs Capital Management LP | History | No change | 575,432 | 21,135 | 1.03% | 1.03% | 14 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Bellevue Group AG | History | No change | 550,000 | 20,201 | 0.43% | 0.43% | 15 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITADEL ADVISORS LLC | History | No change | 523,450 | 19,226 | 0.0% | 0.0% | 16 | 0 | 0.0% | Q2 2026 | Sep 02, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 502,042 | 15,486 | 0.0% | 0.0% | 17 | +290,244 | 137.04% | Q3 2026 | Nov 06, 2026 |
| BlackRock, Inc. | History | No change | 283,833 | 10,425 | 0.0% | 0.0% | 18 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | History | No change | 275,000 | 10,100 | 0.11% | 0.11% | 19 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ExodusPoint Capital Management, LP | History | No change | 218,287 | 8,017 | 0.05% | 0.05% | 20 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BRAIDWELL LP | History | No change | 160,000 | 5,876 | 0.22% | 0.22% | 21 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| MARSHALL WACE, LLP | History | No change | 154,674 | 5,681 | 0.0% | 0.0% | 22 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Woodline Partners LP | History | No change | 150,040 | 5,510 | 0.02% | 0.02% | 23 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | History | No change | 138,030 | 5,069 | 0.23% | 0.23% | 24 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Ensign Peak Advisors, Inc | History | No change | 115,394 | 4,238 | 0.01% | 0.01% | 25 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | No change | 112,499 | 4,132 | 0.0% | 0.0% | 26 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | No change | 108,236 | 3,975 | 0.0% | 0.0% | 27 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| UBS Group AG | History | Added to | 106,659 | 3,289 | 0.0% | 0.0% | 28 | +59,308 | 125.25% | Q3 2026 | Nov 10, 2026 |
| AMERIPRISE FINANCIAL INC | History | No change | 81,928 | 3,009 | 0.0% | 0.0% | 29 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Burkehill Global Management, LP | History | No change | 75,000 | 2,754 | 0.1% | 0.1% | 30 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Opaleye Management Inc. | History | No change | 47,652 | 1,750 | 0.16% | 0.16% | 31 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Parkman Healthcare Partners LLC | History | No change | 45,000 | 1,652 | 0.17% | 0.17% | 32 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NORTHERN TRUST CORP | History | No change | 40,487 | 1,487 | 0.0% | 0.0% | 33 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Ghisallo Capital Management LLC | History | No change | 40,000 | 1,469 | 0.03% | 0.03% | 34 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Bank of New York Mellon Corp | History | New | 45,360 | 1,398 | 0.0% | — | 35 | +45,360 | New | Q3 2026 | Nov 05, 2026 |
| TD ASSET MANAGEMENT INC | History | No change | 33,098 | 1,215 | 0.0% | 0.0% | 36 | 0 | 0.0% | Q2 2026 | Aug 04, 2026 |
| SEVEN GRAND MANAGERS, LLC | History | No change | 30,000 | 1,101 | 0.04% | 0.04% | 37 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Swiss National Bank | History | New | 30,700 | 946 | 0.0% | — | 38 | +30,700 | New | Q3 2026 | Nov 12, 2026 |
| SOROS FUND MANAGEMENT LLC | History | No change | 25,000 | 918 | 0.01% | 0.01% | 39 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Nuveen, LLC | History | New | 29,387 | 906 | 0.0% | — | 40 | +29,387 | New | Q3 2026 | Nov 10, 2026 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | History | No change | 18,720 | 687 | 0.0% | 0.0% | 41 | 0 | 0.0% | Q2 2026 | Sep 09, 2026 |
| RHUMBLINE ADVISERS | History | New | 21,633 | 667 | 0.0% | — | 42 | +21,633 | New | Q3 2026 | Nov 10, 2026 |
| GSA CAPITAL PARTNERS LLP | History | No change | 17,661 | 649 | 0.04% | 0.04% | 43 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| XTX Topco Ltd | History | No change | 17,389 | 638 | 0.01% | 0.01% | 44 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DEUTSCHE BANK AG\ | History | New | 17,861 | 550 | 0.0% | — | 45 | +17,861 | New | Q3 2026 | Nov 06, 2026 |
| Hudson Bay Capital Management LP | History | No change | 12,202 | 448 | 0.0% | 0.0% | 46 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Schonfeld Strategic Advisors LLC | History | No change | 10,813 | 397 | 0.0% | 0.0% | 47 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Weiss Asset Management LP | History | No change | 10,000 | 367 | 0.0% | 0.0% | 48 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITIGROUP INC | History | Added to | 10,519 | 324 | 0.0% | 0.0% | 49 | +8,424 | 402.1% | Q3 2026 | Nov 04, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | History | No change | 8,169 | 300 | 0.0% | 0.0% | 50 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Vanguard Global Advisers, LLC | History | No change | 7,616 | 279 | 0.0% | 0.0% | 51 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| PROFUND ADVISORS LLC | History | New | 7,961 | 245 | 0.01% | — | 52 | +7,961 | New | Q3 2026 | Oct 28, 2026 |
| BARCLAYS PLC | History | Added to | 7,664 | 236 | 0.0% | 0.0% | 53 | +6,653 | 658.06% | Q3 2026 | Nov 06, 2026 |
| China Universal Asset Management Co., Ltd. | History | Added to | 6,400 | 208 | 0.01% | 0.01% | 55 | +2,800 | 77.78% | Q3 2026 | Oct 27, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | No change | 5,680 | 208 | 0.0% | 0.0% | 54 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | History | New | 6,543 | 201 | 0.0% | — | 56 | +6,543 | New | Q3 2026 | Nov 10, 2026 |
| STRS OHIO | History | New | 5,400 | 166 | 0.0% | — | 57 | +5,400 | New | Q3 2026 | Oct 30, 2026 |
| Police & Firemen's Retirement System of New Jersey | History | New | 5,230 | 161 | 0.0% | — | 58 | +5,230 | New | Q3 2026 | Nov 09, 2026 |
| MORGAN STANLEY | History | No change | 4,078 | 149 | 0.0% | 0.0% | 59 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| KLP KAPITALFORVALTNING AS | History | New | 3,500 | 107 | 0.0% | — | 60 | +3,500 | New | Q3 2026 | Nov 10, 2026 |
| Russell Investments Group, Ltd. | History | New | 1,490 | 45 | 0.0% | — | 61 | +1,490 | New | Q3 2026 | Nov 06, 2026 |
| Sterling Capital Management LLC | History | New | 548 | 16 | 0.0% | — | 62 | +548 | New | Q3 2026 | Oct 22, 2026 |
| ROYAL BANK OF CANADA | History | No change | 248 | 9 | 0.0% | 0.0% | 63 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NISA INVESTMENT ADVISORS, LLC | History | New | 80 | 2 | 0.0% | — | 64 | +80 | New | Q3 2026 | Oct 20, 2026 |
| Global Retirement Partners, LLC | History | New | 55 | 1 | 0.0% | — | 65 | +55 | New | Q3 2026 | Nov 10, 2026 |
| Aberdeen Group plc | History | Closed out | 0 | 0 | — | 0.0% | — | -52,117 | -100.0% | Q3 2026 | Nov 10, 2026 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | History | Closed out | 0 | 0 | — | 0.03% | — | -13,183 | -100.0% | Q3 2026 | Nov 10, 2026 |
| Squarepoint Ops LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -6,252 | -100.0% | Q3 2026 | Nov 09, 2026 |
| Farther Finance Advisors, LLC | History | New | 3 | 0 | — | — | — | +3 | New | Q3 2026 | Oct 08, 2026 |
| JONES FINANCIAL COMPANIES LLLP | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Tower Research Capital LLC (TRC) | History | No change | 1 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |