Karyopharm Therapeutics Inc. - KPTI
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | History | Added to | 2,573,435 | 14,334 | 1.16% | 0.31% | 1 | +2,028,881 | 372.58% | Q1 2026 | May 15, 2026 |
| Commodore Capital LP | History | New | 1,950,000 | 10,861 | 0.63% | — | 2 | +1,950,000 | New | Q1 2026 | May 15, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | History | New | 1,917,354 | 10,679 | 0.11% | — | 3 | +1,917,354 | New | Q1 2026 | May 15, 2026 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | Added to | 1,806,322 | 10,061 | 0.02% | 0.0% | 4 | +1,385,000 | 328.73% | Q1 2026 | May 15, 2026 |
| T. Rowe Price Investment Management, Inc. | History | Added to | 1,542,090 | 8,590 | 0.01% | 0.0% | 5 | +956,182 | 163.2% | Q1 2026 | May 15, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Added to | 1,315,038 | 7,324 | 0.0% | 0.0% | 6 | +480,140 | 57.51% | Q1 2026 | May 15, 2026 |
| Caption Management, LLC | History | New | 1,181,900 | 6,583 | 0.04% | — | 7 | +1,181,900 | New | Q1 2026 | May 15, 2026 |
| GOLDMAN SACHS GROUP INC | History | New | 947,579 | 5,278 | 0.0% | — | 8 | +947,579 | New | Q1 2026 | May 15, 2026 |
| Catalio Capital Management, LP | History | Added to | 897,709 | 5,000 | 1.04% | 0.19% | 9 | +754,725 | 527.84% | Q1 2026 | May 15, 2026 |
| BOOTHBAY FUND MANAGEMENT, LLC | History | Added to | 750,410 | 4,179 | 0.05% | 0.02% | 10 | +605,782 | 418.86% | Q1 2026 | May 15, 2026 |
| Squadron Capital Management LLC | History | New | 750,000 | 4,177 | 1.53% | — | 11 | +750,000 | New | Q1 2026 | May 15, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | New | 739,745 | 4,120 | 0.0% | — | 12 | +739,745 | New | Q1 2026 | May 15, 2026 |
| VANGUARD GROUP INC | History | No change | 559,619 | 4,118 | 0.0% | 0.0% | 13 | 0 | 0.0% | Q4 2025 | Jan 29, 2026 |
| Avidity Partners Management LP | History | Added to | 463,741 | 3,853 | 0.87% | 0.29% | 14 | +329,175 | 244.62% | Q1 2026 | May 13, 2026 |
| JANE STREET GROUP, LLC | History | Added to | 593,701 | 3,306 | 0.0% | 0.0% | 15 | +502,368 | 550.04% | Q1 2026 | May 12, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | New | 511,571 | 2,849 | 0.0% | — | 16 | +511,571 | New | Q1 2026 | May 15, 2026 |
| CITADEL ADVISORS LLC | History | Added to | 507,500 | 2,826 | 0.0% | 0.0% | 17 | +371,991 | 274.51% | Q1 2026 | May 15, 2026 |
| Affinity Asset Advisors, LLC | History | Reduced | 500,000 | 2,785 | 0.14% | 0.37% | 18 | -389,575 | -43.79% | Q1 2026 | May 14, 2026 |
| Soleus Capital Management, L.P. | History | No change | 440,000 | 2,450 | 0.1% | 0.12% | 19 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| ADAR1 Capital Management, LLC | History | Added to | 341,936 | 1,904 | 0.11% | 0.03% | 20 | +291,936 | 583.87% | Q1 2026 | May 15, 2026 |
| GROUP ONE TRADING LLC | History | Added to | 340,227 | 1,895 | 0.0% | 0.0% | 21 | +159,308 | 88.05% | Q1 2026 | May 13, 2026 |
| Boxer Capital Management, LLC | History | Added to | 302,536 | 1,685 | 0.22% | 0.41% | 22 | +50,000 | 19.8% | Q1 2026 | May 15, 2026 |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | History | Reduced | 300,000 | 1,671 | 0.02% | 0.04% | 23 | -10,020 | -3.23% | Q1 2026 | May 15, 2026 |
| Eversept Partners, LP | History | New | 299,974 | 1,670 | 0.09% | — | 24 | +299,974 | New | Q1 2026 | May 15, 2026 |
| ACORN CAPITAL ADVISORS, LLC | History | New | 287,826 | 1,603 | 0.46% | — | 25 | +287,826 | New | Q1 2026 | May 15, 2026 |
| Jump Financial, LLC | History | Added to | 262,146 | 1,460 | 0.02% | 0.0% | 26 | +208,330 | 387.12% | Q1 2026 | May 14, 2026 |
| Trexquant Investment LP | History | Added to | 257,903 | 1,436 | 0.01% | 0.0% | 27 | +216,170 | 517.98% | Q1 2026 | May 15, 2026 |
| Ally Bridge Group (NY) LLC | History | New | 250,000 | 1,392 | 1.12% | — | 28 | +250,000 | New | Q1 2026 | May 15, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | Added to | 248,957 | 1,382 | 0.0% | 0.0% | 29 | +245,231 | 6581.62% | Q1 2026 | May 13, 2026 |
| BlackRock, Inc. | History | Reduced | 244,899 | 1,364 | 0.0% | 0.0% | 30 | -2,659 | -1.07% | Q1 2026 | May 13, 2026 |
| DIADEMA PARTNERS LP | History | New | 241,300 | 1,344 | 0.23% | — | 31 | +241,300 | New | Q1 2026 | May 15, 2026 |
| Brevan Howard Capital Management LP | History | New | 212,367 | 1,182 | 0.01% | — | 32 | +212,367 | New | Q1 2026 | May 15, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 206,133 | 1,148 | 0.0% | 0.0% | 33 | +18,399 | 9.8% | Q1 2026 | May 15, 2026 |
| UBS Group AG | History | Added to | 194,017 | 1,080 | 0.0% | 0.0% | 34 | +105,562 | 119.34% | Q1 2026 | May 05, 2026 |
| BALYASNY ASSET MANAGEMENT L.P. | History | New | 170,748 | 951 | 0.0% | — | 35 | +170,748 | New | Q1 2026 | May 15, 2026 |
| SILVERBACK ASSET MANAGEMENT LLC | History | Added to | 165,000 | 919 | 0.13% | 0.04% | 36 | +125,000 | 312.5% | Q1 2026 | May 21, 2026 |
| XTX Topco Ltd | History | Added to | 164,443 | 915 | 0.02% | 0.0% | 37 | +152,539 | 1281.41% | Q1 2026 | May 15, 2026 |
| SIMPLEX TRADING, LLC | History | Reduced | 156,900 | 873 | 0.0% | 0.0% | 38 | -7,768 | -4.72% | Q1 2026 | May 14, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | Added to | 151,232 | 842 | 0.0% | 0.0% | 39 | +2,439 | 1.64% | Q1 2026 | May 15, 2026 |
| MARSHALL WACE, LLP | History | No change | 128,451 | 715 | 0.0% | 0.0% | 40 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| TWO SIGMA ADVISERS, LP | History | No change | 89,729 | 660 | 0.0% | 0.0% | 41 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | New | 114,934 | 640 | 0.0% | — | 42 | +114,934 | New | Q1 2026 | May 08, 2026 |
| Engineers Gate Manager LP | History | New | 112,432 | 626 | 0.01% | — | 43 | +112,432 | New | Q1 2026 | May 15, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | Added to | 105,414 | 587 | 0.0% | 0.0% | 44 | +45,500 | 75.94% | Q1 2026 | May 14, 2026 |
| Tetragon Partners GP Ltd | History | New | 102,984 | 573 | 0.11% | — | 45 | +102,984 | New | Q1 2026 | May 15, 2026 |
| C WorldWide Group Holding A/S | History | No change | 100,000 | 557 | 0.01% | 0.01% | 46 | 0 | 0.0% | Q1 2026 | May 06, 2026 |
| Birchview Capital, LP | History | New | 83,952 | 467 | 0.27% | — | 47 | +83,952 | New | Q1 2026 | May 15, 2026 |
| STATE STREET CORP | History | Added to | 80,742 | 449 | 0.0% | 0.0% | 48 | +21,800 | 36.99% | Q1 2026 | May 15, 2026 |
| Connor, Clark & Lunn Investment Management Ltd. | History | Added to | 79,081 | 440 | 0.0% | 0.0% | 49 | +21,869 | 38.22% | Q1 2026 | May 11, 2026 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | History | Added to | 71,873 | 400 | 0.01% | 0.01% | 50 | +6,000 | 9.11% | Q1 2026 | May 15, 2026 |
| ROYAL BANK OF CANADA | History | Added to | 60,399 | 336 | 0.0% | 0.0% | 51 | +2,399 | 4.14% | Q1 2026 | May 15, 2026 |
| DAFNA Capital Management LLC | History | Reduced | 45,800 | 255 | 0.06% | 0.09% | 52 | -5,200 | -10.2% | Q1 2026 | May 15, 2026 |
| NORTHERN TRUST CORP | History | Added to | 38,556 | 214 | 0.0% | 0.0% | 53 | +9,533 | 32.85% | Q1 2026 | May 14, 2026 |
| Zimmer Partners, LP | History | New | 37,500 | 208 | 0.01% | — | 54 | +37,500 | New | Q1 2026 | May 15, 2026 |
| Centiva Capital, LP | History | New | 33,810 | 188 | 0.0% | — | 55 | +33,810 | New | Q1 2026 | May 14, 2026 |
| Point72 Asset Management, L.P. | History | New | 30,000 | 167 | 0.0% | — | 56 | +30,000 | New | Q1 2026 | May 15, 2026 |
| China Universal Asset Management Co., Ltd. | History | New | 30,000 | 167 | 0.01% | — | 57 | +30,000 | New | Q1 2026 | Apr 27, 2026 |
| Baird Financial Group, Inc. | History | Added to | 29,791 | 165 | 0.0% | 0.0% | 58 | +1,798 | 6.42% | Q1 2026 | May 14, 2026 |
| Susquehanna Portfolio Strategies, LLC | History | New | 25,021 | 139 | 0.0% | — | 59 | +25,021 | New | Q1 2026 | May 15, 2026 |
| BANK OF AMERICA CORP /DE/ | History | Reduced | 19,472 | 108 | 0.0% | 0.0% | 60 | -28,616 | -59.51% | Q1 2026 | May 15, 2026 |
| OMERS ADMINISTRATION Corp | History | New | 19,400 | 108 | 0.0% | — | 61 | +19,400 | New | Q1 2026 | May 15, 2026 |
| MORGAN STANLEY | History | Added to | 18,570 | 103 | 0.0% | 0.0% | 62 | +9,712 | 109.64% | Q1 2026 | May 15, 2026 |
| Invesco Ltd. | History | New | 16,738 | 93 | 0.0% | — | 63 | +16,738 | New | Q1 2026 | May 12, 2026 |
| Velan Capital Investment Management LP | History | New | 15,000 | 83 | 0.05% | — | 64 | +15,000 | New | Q1 2026 | May 15, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | New | 13,429 | 74 | 0.0% | — | 65 | +13,429 | New | Q1 2026 | May 15, 2026 |
| HSBC HOLDINGS PLC | History | New | 11,495 | 65 | 0.0% | — | 66 | +11,495 | New | Q1 2026 | Apr 30, 2026 |
| Bank of New York Mellon Corp | History | Added to | 11,399 | 63 | 0.0% | 0.0% | 67 | +312 | 2.81% | Q1 2026 | May 05, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | No change | 10,886 | 61 | 0.0% | 0.0% | 68 | 0 | 0.0% | Q1 2026 | May 15, 2026 |
| Vanguard Global Advisers, LLC | History | New | 8,207 | 45 | 0.0% | — | 69 | +8,207 | New | Q1 2026 | May 08, 2026 |
| BARCLAYS PLC | History | Added to | 7,424 | 41 | 0.0% | 0.0% | 70 | +3,315 | 80.68% | Q1 2026 | May 14, 2026 |
| CITIGROUP INC | History | Added to | 4,941 | 27 | 0.0% | — | 71 | +4,940 | 494000.0% | Q1 2026 | May 11, 2026 |
| TD Waterhouse Canada Inc. | History | No change | 3,203 | 18 | 0.0% | 0.0% | 72 | 0 | 0.0% | Q1 2026 | May 12, 2026 |
| Rockefeller Capital Management L.P. | History | No change | 733 | 4 | 0.0% | 0.0% | 73 | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| FMR LLC | History | Reduced | 665 | 3 | 0.0% | 0.0% | 74 | -14 | -2.06% | Q1 2026 | May 15, 2026 |
| Persistent Asset Partners Ltd | History | Reduced | 610 | 2 | 0.0% | 0.06% | 77 | -17,706 | -96.67% | Q1 2026 | May 12, 2026 |
| JPMORGAN CHASE & CO | History | Reduced | 471 | 2 | 0.0% | 0.0% | 75 | -1,270 | -72.95% | Q1 2026 | May 13, 2026 |
| OSAIC HOLDINGS, INC. | History | Added to | 402 | 2 | 0.0% | 0.0% | 76 | +120 | 42.55% | Q1 2026 | May 15, 2026 |
| HARBOUR INVESTMENTS, INC. | History | Added to | 285 | 1 | 0.0% | — | 78 | +200 | 235.29% | Q1 2026 | May 15, 2026 |
| Quent Capital, LLC | History | No change | 235 | 1 | 0.0% | 0.0% | 79 | 0 | 0.0% | Q1 2026 | Apr 28, 2026 |
| Opaleye Management Inc. | History | Closed out | 0 | 0 | — | 0.9% | — | -930,000 | -100.0% | Q1 2026 | May 15, 2026 |
| BRAIDWELL LP | History | Closed out | 0 | 0 | — | 0.07% | — | -303,370 | -100.0% | Q1 2026 | May 15, 2026 |
| Exome Asset Management LLC | History | Closed out | 0 | 0 | — | 1.04% | — | -295,541 | -100.0% | Q1 2026 | May 15, 2026 |
| AMERIPRISE FINANCIAL INC | History | Closed out | 0 | 0 | — | 0.0% | — | -276,881 | -100.0% | Q1 2026 | May 15, 2026 |
| Walleye Capital LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -95,672 | -100.0% | Q1 2026 | May 13, 2026 |
| Context Capital Management, LLC | History | Closed out | 0 | 0 | — | 0.01% | — | -62,995 | -100.0% | Q1 2026 | May 07, 2026 |
| Quadrature Capital Ltd | History | Closed out | 0 | 0 | — | 0.0% | — | -59,708 | -100.0% | Q1 2026 | May 15, 2026 |
| PRELUDE CAPITAL MANAGEMENT, LLC | History | Closed out | 0 | 0 | — | 0.02% | — | -28,723 | -100.0% | Q1 2026 | May 15, 2026 |
| TUDOR INVESTMENT CORP ET AL | History | Closed out | 0 | 0 | — | 0.0% | — | -12,922 | -100.0% | Q1 2026 | May 15, 2026 |
| Belvedere Trading LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -12,300 | -100.0% | Q1 2026 | May 12, 2026 |
| Corient Private Wealth LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -10,039 | -100.0% | Q1 2026 | May 15, 2026 |
| Aspect Partners, LLC | History | Closed out | 0 | 0 | — | 0.0% | — | -391 | -100.0% | Q1 2026 | Apr 02, 2026 |
| Advisory Services Network, LLC | History | New | 12 | 0 | — | — | — | +12 | New | Q1 2026 | May 15, 2026 |
| SBI Securities Co., Ltd. | History | Reduced | 67 | 0 | — | — | — | -7 | -9.46% | Q1 2026 | Apr 27, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | Added to | 84 | 0 | — | — | — | +2 | 2.44% | Q1 2026 | May 12, 2026 |
| PlanVest Financial, Inc | History | New | 1 | 0 | — | — | — | +1 | New | Q1 2026 | May 14, 2026 |
| CIBC Private Wealth Group LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |
| Allworth Financial LP | History | No change | 26 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | May 14, 2026 |
| West Branch Capital LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | Apr 14, 2026 |
| Activest Wealth Management | History | No change | 66 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | Apr 15, 2026 |
| MB, LEVIS & ASSOCIATES, LLC | History | No change | 100 | 0 | — | — | — | 0 | 0.0% | Q1 2026 | Apr 07, 2026 |