Karyopharm Therapeutics Inc. - KPTI
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | History | No change | 1,917,354 | 18,732 | 0.16% | 0.16% | 1 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | No change | 1,521,322 | 14,863 | 0.02% | 0.02% | 2 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ACORN CAPITAL ADVISORS, LLC | History | No change | 1,518,113 | 14,831 | 4.05% | 4.05% | 3 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| GOLDMAN SACHS GROUP INC | History | No change | 1,424,658 | 13,918 | 0.0% | 0.0% | 4 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BlackRock, Inc. | History | No change | 1,418,799 | 13,861 | 0.0% | 0.0% | 5 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | No change | 958,979 | 9,369 | 0.0% | 0.0% | 6 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Catalio Capital Management, LP | History | No change | 940,855 | 9,192 | 1.73% | 1.73% | 7 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Avidity Partners Management LP | History | No change | 924,487 | 9,032 | 1.45% | 1.45% | 8 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| T. Rowe Price Investment Management, Inc. | History | No change | 786,309 | 7,683 | 0.01% | 0.01% | 9 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | No change | 695,264 | 6,792 | 0.0% | 0.0% | 10 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Kalehua Capital Management LLC | History | No change | 685,644 | 6,698 | 4.8% | 4.8% | 11 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NEA Management Company, LLC | History | No change | 576,780 | 5,635 | 0.35% | 0.35% | 12 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | No change | 545,700 | 5,331 | 0.0% | 0.0% | 13 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | No change | 531,231 | 5,191 | 0.0% | 0.0% | 14 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| Ghisallo Capital Management LLC | History | No change | 500,000 | 4,885 | 0.1% | 0.1% | 15 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Soleus Capital Management, L.P. | History | No change | 440,000 | 4,298 | 0.15% | 0.15% | 16 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| Caption Management, LLC | History | No change | 378,200 | 3,695 | 0.02% | 0.02% | 17 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| UBS Group AG | History | No change | 353,545 | 3,454 | 0.0% | 0.0% | 18 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | No change | 341,676 | 3,338 | 0.0% | 0.0% | 19 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| STATE STREET CORP | History | No change | 325,991 | 3,184 | 0.0% | 0.0% | 20 | 0 | 0.0% | Q2 2026 | Sep 22, 2026 |
| Affinity Asset Advisors, LLC | History | No change | 312,500 | 3,053 | 0.14% | 0.14% | 21 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Brevan Howard Capital Management LP | History | No change | 309,817 | 3,026 | 0.02% | 0.02% | 22 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Boxer Capital Management, LLC | History | No change | 302,536 | 2,955 | 0.22% | 0.22% | 23 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | History | No change | 300,000 | 2,931 | 0.03% | 0.03% | 24 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | No change | 298,997 | 2,916 | 0.0% | 0.0% | 25 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| SILVERARC CAPITAL MANAGEMENT, LLC | History | No change | 297,460 | 2,906 | 0.3% | 0.3% | 26 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Eversept Partners, LP | History | No change | 276,174 | 2,698 | 0.14% | 0.14% | 27 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Tetragon Partners GP Ltd | History | No change | 250,300 | 2,445 | 0.39% | 0.39% | 28 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| JPMORGAN CHASE & CO | History | No change | 207,609 | 2,093 | 0.0% | 0.0% | 29 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| MORGAN STANLEY | History | No change | 202,506 | 1,978 | 0.0% | 0.0% | 30 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Trexquant Investment LP | History | No change | 188,368 | 1,840 | 0.01% | 0.01% | 31 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | No change | 188,038 | 1,837 | 0.0% | 0.0% | 32 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| DLD Asset Management, LP | History | No change | 181,600 | 1,770 | 0.12% | 0.12% | 33 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| BARCLAYS PLC | History | No change | 165,904 | 1,620 | 0.0% | 0.0% | 34 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NORTHERN TRUST CORP | History | No change | 160,006 | 1,563 | 0.0% | 0.0% | 35 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | No change | 145,401 | 1,420 | 0.0% | 0.0% | 36 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| J. Goldman & Co LP | History | No change | 135,100 | 1,319 | 0.03% | 0.03% | 37 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | History | No change | 134,818 | 1,317 | 0.0% | 0.0% | 38 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| SILVERBACK ASSET MANAGEMENT LLC | History | No change | 130,000 | 1,270 | 0.14% | 0.14% | 39 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| MARSHALL WACE, LLP | History | No change | 128,451 | 1,254 | 0.0% | 0.0% | 40 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| CITADEL ADVISORS LLC | History | No change | 117,969 | 1,152 | 0.0% | 0.0% | 41 | 0 | 0.0% | Q2 2026 | Sep 02, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | No change | 108,214 | 1,057 | 0.0% | 0.0% | 42 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Jump Financial, LLC | History | No change | 94,000 | 918 | 0.01% | 0.01% | 43 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Invesco Ltd. | History | No change | 90,304 | 882 | 0.0% | 0.0% | 44 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| JANE STREET GROUP, LLC | History | No change | 86,273 | 842 | 0.0% | 0.0% | 45 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Connor, Clark & Lunn Investment Management Ltd. | History | No change | 76,397 | 746 | 0.0% | 0.0% | 46 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | History | No change | 71,873 | 702 | 0.01% | 0.01% | 47 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| STRS OHIO | History | New | 542,500 | 661 | 0.0% | — | 48 | +542,500 | New | Q3 2026 | Oct 30, 2026 |
| Squarepoint Ops LLC | History | No change | 63,801 | 623 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | No change | 61,943 | 605 | 0.0% | 0.0% | 50 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ROYAL BANK OF CANADA | History | No change | 60,430 | 590 | 0.0% | 0.0% | 51 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Bank of New York Mellon Corp | History | No change | 57,262 | 559 | 0.0% | 0.0% | 52 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| Susquehanna Portfolio Strategies, LLC | History | No change | 54,545 | 532 | 0.01% | 0.01% | 53 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| XTX Topco Ltd | History | No change | 53,272 | 520 | 0.01% | 0.01% | 54 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BANK OF AMERICA CORP /DE/ | History | No change | 49,924 | 487 | 0.0% | 0.0% | 55 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Birchview Capital, LP | History | No change | 42,952 | 419 | 0.2% | 0.2% | 56 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Nuveen, LLC | History | No change | 37,868 | 369 | 0.0% | 0.0% | 57 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| Engineers Gate Manager LP | History | No change | 33,966 | 331 | 0.0% | 0.0% | 58 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | History | No change | 33,333 | 326 | 0.0% | 0.0% | 59 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Context Capital Management, LLC | History | New | 263,696 | 321 | 0.01% | — | 60 | +263,696 | New | Q3 2026 | Nov 04, 2026 |
| TORONTO DOMINION BANK | History | No change | 30,930 | 302 | 0.0% | 0.0% | 61 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Baird Financial Group, Inc. | History | No change | 29,791 | 291 | 0.0% | 0.0% | 62 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | No change | 27,225 | 266 | 0.0% | 0.0% | 63 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| ExodusPoint Capital Management, LP | History | No change | 26,582 | 259 | 0.0% | 0.0% | 64 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| RHUMBLINE ADVISERS | History | No change | 23,467 | 229 | 0.0% | 0.0% | 65 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | History | No change | 23,265 | 227 | 0.0% | 0.0% | 66 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Velan Capital Investment Management LP | History | No change | 20,000 | 195 | 0.12% | 0.12% | 67 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DEUTSCHE BANK AG\ | History | No change | 19,425 | 189 | 0.0% | 0.0% | 68 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| WELLS FARGO & COMPANY/MN | History | No change | 16,903 | 165 | 0.0% | 0.0% | 69 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| SEI INVESTMENTS CO | History | No change | 15,083 | 147 | 0.0% | 0.0% | 70 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| HSBC HOLDINGS PLC | History | No change | 13,750 | 137 | 0.0% | 0.0% | 71 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Headlands Technologies LLC | History | No change | 12,113 | 118 | 0.01% | 0.01% | 72 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| MetLife Investment Management, LLC | History | No change | 12,017 | 117 | 0.0% | 0.0% | 73 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Virtu Financial LLC | History | No change | 10,728 | 105 | 0.0% | 0.0% | 74 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Quadrature Capital Ltd | History | No change | 10,296 | 100 | 0.0% | 0.0% | 75 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| SIMPLEX TRADING, LLC | History | Added to | 75,637 | 92 | 0.0% | 0.0% | 76 | +42,651 | 129.3% | Q3 2026 | Nov 04, 2026 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | History | No change | 9,171 | 89 | 0.0% | 0.0% | 77 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| FMR LLC | History | No change | 8,936 | 87 | 0.0% | 0.0% | 78 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Vanguard Global Advisers, LLC | History | No change | 8,207 | 80 | 0.0% | 0.0% | 79 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| CITIGROUP INC | History | Added to | 47,191 | 57 | 0.0% | 0.0% | 80 | +9,274 | 24.46% | Q3 2026 | Nov 04, 2026 |
| Police & Firemen's Retirement System of New Jersey | History | No change | 5,874 | 57 | 0.0% | 0.0% | 81 | 0 | 0.0% | Q2 2026 | Jul 23, 2026 |
| NEW YORK STATE COMMON RETIREMENT FUND | History | No change | 5,600 | 54 | 0.0% | 0.0% | 82 | 0 | 0.0% | Q2 2026 | Jul 29, 2026 |
| China Universal Asset Management Co., Ltd. | History | Added to | 36,000 | 43 | 0.0% | 0.01% | 83 | +11,000 | 44.0% | Q3 2026 | Oct 27, 2026 |
| StoneX Group Inc. | History | New | 17,019 | 25 | 0.0% | — | 84 | +17,019 | New | Q3 2026 | Nov 03, 2026 |
| Legal & General Group Plc | History | No change | 1,935 | 18 | 0.0% | 0.0% | 85 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Ameritas Investment Partners, Inc. | History | No change | 1,808 | 17 | 0.0% | 0.0% | 86 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Russell Investments Group, Ltd. | History | No change | 1,592 | 15 | 0.0% | 0.0% | 87 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| GROUP ONE TRADING LLC | History | No change | 1,400 | 13 | 0.0% | 0.0% | 88 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Tower Research Capital LLC (TRC) | History | No change | 1,259 | 12 | 0.0% | 0.0% | 89 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| TD Waterhouse Canada Inc. | History | No change | 5,707 | 4 | 0.0% | 0.0% | 90 | 0 | 0.0% | Q3 2026 | Oct 16, 2026 |
| OSAIC HOLDINGS, INC. | History | No change | 402 | 3 | 0.0% | 0.0% | 91 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| HARBOUR INVESTMENTS, INC. | History | No change | 285 | 2 | 0.0% | 0.0% | 92 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | History | No change | 274 | 2 | 0.0% | 0.0% | 93 | 0 | 0.0% | Q2 2026 | Aug 24, 2026 |
| GAMMA Investing LLC | History | New | 865 | 1 | 0.0% | — | 95 | +865 | New | Q3 2026 | Oct 08, 2026 |
| Quent Capital, LLC | History | No change | 166 | 1 | 0.0% | 0.0% | 94 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| C WorldWide Group Holding A/S | History | Closed out | 0 | 0 | — | 0.02% | — | -100,000 | -100.0% | Q3 2026 | Nov 04, 2026 |
| Y-Intercept (Hong Kong) Ltd | History | Closed out | 0 | 0 | — | 0.0% | — | -10,375 | -100.0% | Q3 2026 | Oct 16, 2026 |
| Owl Creek Wealth Partners LLC | History | New | 685 | 0 | — | — | — | +685 | New | Q3 2026 | Oct 20, 2026 |
| Caitong International Asset Management Co., Ltd | History | Added to | 249 | 0 | — | — | — | +235 | 1678.57% | Q3 2026 | Oct 29, 2026 |
| Farther Finance Advisors, LLC | History | New | 66 | 0 | — | — | — | +66 | New | Q3 2026 | Oct 08, 2026 |
| EverSource Wealth Advisors, LLC | History | New | 15 | 0 | — | — | — | +15 | New | Q3 2026 | Nov 04, 2026 |
| Sterling Capital Management LLC | History | Reduced | 340 | 0 | — | 0.0% | — | -12 | -3.41% | Q3 2026 | Oct 22, 2026 |
| IFP Advisors, Inc | History | New | 7 | 0 | — | — | — | +7 | New | Q3 2026 | Oct 16, 2026 |
| SBI Securities Co., Ltd. | History | Added to | 69 | 0 | — | — | — | +2 | 2.99% | Q3 2026 | Oct 21, 2026 |
| Allworth Financial LP | History | No change | 26 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| West Branch Capital LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Oct 20, 2026 |
| Activest Wealth Management | History | No change | 66 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Oct 15, 2026 |
| MB, LEVIS & ASSOCIATES, LLC | History | No change | 100 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Oct 15, 2026 |
| PlanVest Financial, Inc | History | No change | 1 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 10, 2026 |