Karyopharm Therapeutics Inc. - KPTI
Detailed investor-level table based on 13F positions.
Early Q1 2026 data: only 3 institutional holders reported so far. The full shareholder list will grow as more funds file with the SEC.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | History | New | 930,000 | 6,844 | 0.9% | — | 1 | +930,000 | New | Q4 2025 | Apr 13, 2026 |
| Affinity Asset Advisors, LLC | History | Added to | 889,575 | 6,547 | 0.37% | 0.09% | 2 | +731,975 | 464.45% | Q4 2025 | Feb 13, 2026 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | History | Added to | 834,898 | 6,144 | 0.0% | 0.0% | 3 | +552,859 | 196.02% | Q4 2025 | Feb 17, 2026 |
| T. Rowe Price Investment Management, Inc. | History | Reduced | 585,908 | 4,313 | 0.0% | 0.0% | 4 | -115,084 | -16.42% | Q4 2025 | Feb 19, 2026 |
| VANGUARD GROUP INC | History | Added to | 559,619 | 4,118 | 0.0% | 0.0% | 5 | +151,397 | 37.09% | Q4 2025 | Jan 29, 2026 |
| Ikarian Capital, LLC | History | Added to | 544,554 | 4,007 | 0.31% | 0.02% | 6 | +517,297 | 1897.85% | Q4 2025 | Feb 18, 2026 |
| Soleus Capital Management, L.P. | History | New | 440,000 | 3,238 | 0.12% | — | 7 | +440,000 | New | Q4 2025 | Feb 12, 2026 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | History | No change | 421,322 | 3,100 | 0.0% | 0.0% | 8 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | History | New | 310,020 | 2,281 | 0.04% | — | 9 | +310,020 | New | Q4 2025 | Feb 17, 2026 |
| BRAIDWELL LP | History | New | 303,370 | 2,232 | 0.07% | — | 10 | +303,370 | New | Q4 2025 | Feb 17, 2026 |
| Exome Asset Management LLC | History | Added to | 295,541 | 2,175 | 1.04% | 0.19% | 11 | +247,441 | 514.43% | Q4 2025 | Feb 13, 2026 |
| AMERIPRISE FINANCIAL INC | History | New | 276,881 | 2,037 | 0.0% | — | 12 | +276,881 | New | Q4 2025 | Feb 17, 2026 |
| Boxer Capital Management, LLC | History | New | 252,536 | 1,858 | 0.41% | — | 13 | +252,536 | New | Q4 2025 | Feb 17, 2026 |
| BlackRock, Inc. | History | Added to | 247,558 | 1,822 | 0.0% | 0.0% | 14 | +15,607 | 6.73% | Q4 2025 | Feb 12, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | Added to | 187,734 | 1,381 | 0.0% | 0.0% | 15 | +94,445 | 101.24% | Q4 2025 | Feb 09, 2026 |
| GROUP ONE TRADING LLC | History | Added to | 180,919 | 1,331 | 0.0% | 0.0% | 16 | +78,683 | 76.96% | Q4 2025 | Feb 12, 2026 |
| SIMPLEX TRADING, LLC | History | Added to | 164,668 | 1,211 | 0.0% | 0.0% | 17 | +110,606 | 204.59% | Q4 2025 | Feb 11, 2026 |
| TWO SIGMA INVESTMENTS, LP | History | New | 148,793 | 1,095 | 0.0% | — | 18 | +148,793 | New | Q4 2025 | Feb 17, 2026 |
| BOOTHBAY FUND MANAGEMENT, LLC | History | New | 144,628 | 1,064 | 0.02% | — | 19 | +144,628 | New | Q4 2025 | Feb 17, 2026 |
| Catalio Capital Management, LP | History | No change | 142,984 | 1,052 | 0.19% | 0.17% | 20 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| CITADEL ADVISORS LLC | History | Added to | 135,509 | 997 | 0.0% | 0.0% | 21 | +43,509 | 47.29% | Q4 2025 | Feb 17, 2026 |
| Avidity Partners Management LP | History | No change | 134,566 | 990 | 0.29% | 0.2% | 22 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| MARSHALL WACE, LLP | History | No change | 128,451 | 945 | 0.0% | 0.0% | 23 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| C WorldWide Group Holding A/S | History | No change | 100,000 | 736 | 0.01% | 0.01% | 24 | 0 | 0.0% | Q4 2025 | Feb 04, 2026 |
| Walleye Capital LLC | History | New | 95,672 | 704 | 0.0% | — | 25 | +95,672 | New | Q4 2025 | Feb 13, 2026 |
| JANE STREET GROUP, LLC | History | Added to | 91,333 | 672 | 0.0% | 0.0% | 26 | +78,433 | 608.01% | Q4 2025 | Feb 12, 2026 |
| TWO SIGMA ADVISERS, LP | History | New | 89,729 | 660 | 0.0% | — | 27 | +89,729 | New | Q4 2025 | Feb 17, 2026 |
| UBS Group AG | History | Added to | 88,455 | 651 | 0.0% | 0.0% | 28 | +28,770 | 48.2% | Q4 2025 | Jan 29, 2026 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | History | Added to | 65,873 | 484 | 0.01% | 0.0% | 29 | +31,000 | 88.89% | Q4 2025 | Feb 17, 2026 |
| Context Capital Management, LLC | History | New | 62,995 | 463 | 0.01% | — | 30 | +62,995 | New | Q4 2025 | Feb 13, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | Reduced | 59,914 | 440 | 0.0% | 0.0% | 31 | -4,800 | -7.42% | Q4 2025 | Feb 12, 2026 |
| Quadrature Capital Ltd | History | New | 59,708 | 439 | 0.0% | — | 32 | +59,708 | New | Q4 2025 | Feb 17, 2026 |
| STATE STREET CORP | History | Added to | 58,942 | 433 | 0.0% | 0.0% | 33 | +12,600 | 27.19% | Q4 2025 | Feb 13, 2026 |
| ROYAL BANK OF CANADA | History | New | 58,000 | 427 | 0.0% | — | 34 | +58,000 | New | Q4 2025 | Feb 17, 2026 |
| Connor, Clark & Lunn Investment Management Ltd. | History | New | 57,212 | 421 | 0.0% | — | 35 | +57,212 | New | Q4 2025 | Feb 10, 2026 |
| Jump Financial, LLC | History | New | 53,816 | 396 | 0.0% | — | 36 | +53,816 | New | Q4 2025 | Feb 17, 2026 |
| DAFNA Capital Management LLC | History | New | 51,000 | 375 | 0.09% | — | 37 | +51,000 | New | Q4 2025 | Feb 17, 2026 |
| ADAR1 Capital Management, LLC | History | Added to | 50,000 | 368 | 0.03% | 0.02% | 38 | +25,000 | 100.0% | Q4 2025 | Feb 18, 2026 |
| BANK OF AMERICA CORP /DE/ | History | Added to | 48,088 | 353 | 0.0% | — | 39 | +47,994 | 51057.45% | Q4 2025 | Feb 17, 2026 |
| Trexquant Investment LP | History | New | 41,733 | 307 | 0.0% | — | 40 | +41,733 | New | Q4 2025 | Feb 17, 2026 |
| SILVERBACK ASSET MANAGEMENT LLC | History | No change | 40,000 | 294 | 0.04% | 0.02% | 41 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| NORTHERN TRUST CORP | History | Added to | 29,023 | 213 | 0.0% | 0.0% | 42 | +10,147 | 53.76% | Q4 2025 | Feb 17, 2026 |
| PRELUDE CAPITAL MANAGEMENT, LLC | History | New | 28,723 | 211 | 0.02% | — | 43 | +28,723 | New | Q4 2025 | Feb 17, 2026 |
| Baird Financial Group, Inc. | History | Added to | 27,993 | 206 | 0.0% | 0.0% | 44 | +2,061 | 7.95% | Q4 2025 | Feb 13, 2026 |
| Persistent Asset Partners Ltd | History | New | 18,316 | 134 | 0.06% | — | 45 | +18,316 | New | Q4 2025 | Feb 17, 2026 |
| TUDOR INVESTMENT CORP ET AL | History | New | 12,922 | 95 | 0.0% | — | 46 | +12,922 | New | Q4 2025 | Feb 17, 2026 |
| Belvedere Trading LLC | History | Reduced | 12,300 | 90 | 0.0% | 0.0% | 47 | -2,763 | -18.34% | Q4 2025 | Feb 10, 2026 |
| XTX Topco Ltd | History | Reduced | 11,904 | 87 | 0.0% | 0.0% | 48 | -2,498 | -17.34% | Q4 2025 | Feb 17, 2026 |
| Bank of New York Mellon Corp | History | Added to | 11,087 | 81 | 0.0% | 0.0% | 50 | +1 | 0.01% | Q4 2025 | Feb 10, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | History | No change | 10,886 | 81 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| MORGAN STANLEY | History | Reduced | 8,858 | 65 | 0.0% | 0.0% | 51 | -16,908 | -65.62% | Q4 2025 | Feb 13, 2026 |
| BARCLAYS PLC | History | No change | 4,109 | 30 | 0.0% | 0.0% | 52 | 0 | 0.0% | Q4 2025 | Feb 13, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | History | New | 3,726 | 27 | 0.0% | — | 53 | +3,726 | New | Q4 2025 | Feb 10, 2026 |
| TD Waterhouse Canada Inc. | History | No change | 3,203 | 23 | 0.0% | 0.0% | 54 | 0 | 0.0% | Q4 2025 | Jan 27, 2026 |
| JPMORGAN CHASE & CO | History | Reduced | 1,741 | 12 | 0.0% | 0.0% | 55 | -763,409 | -99.77% | Q4 2025 | Feb 11, 2026 |
| Corient Private Wealth LLC | History | New | 10,039 | 10 | 0.0% | — | 56 | +10,039 | New | Q4 2025 | Mar 09, 2026 |
| Rockefeller Capital Management L.P. | History | New | 733 | 5 | 0.0% | — | 57 | +733 | New | Q4 2025 | Mar 16, 2026 |
| FMR LLC | History | No change | 679 | 4 | 0.0% | 0.0% | 58 | 0 | 0.0% | Q4 2025 | Feb 17, 2026 |
| Aspect Partners, LLC | History | New | 391 | 2 | 0.0% | — | 60 | +391 | New | Q4 2025 | Jan 23, 2026 |
| OSAIC HOLDINGS, INC. | History | Reduced | 282 | 2 | 0.0% | 0.0% | 59 | -64 | -18.5% | Q4 2025 | Feb 17, 2026 |
| Quent Capital, LLC | History | Added to | 235 | 1 | 0.0% | 0.0% | 61 | +4 | 1.73% | Q4 2025 | Jan 29, 2026 |
| Birchview Capital, LP | History | Closed out | 0 | 0 | — | 0.14% | — | -27,985 | -100.0% | Q3 2025 | Nov 13, 2025 |
| GOLDMAN SACHS GROUP INC | History | Closed out | 0 | 0 | — | 0.0% | — | -24,885 | -100.0% | Q3 2025 | Nov 14, 2025 |
| GSA CAPITAL PARTNERS LLP | History | Closed out | 0 | 0 | — | 0.01% | — | -14,076 | -100.0% | Q3 2025 | Nov 07, 2025 |
| NATIONAL BANK OF CANADA /FI/ | History | Closed out | 0 | 0 | — | 0.0% | — | -1,153 | -100.0% | Q3 2025 | Nov 14, 2025 |
| Tower Research Capital LLC (TRC) | History | Closed out | 0 | 0 | — | 0.0% | — | -1,089 | -100.0% | Q3 2025 | Nov 14, 2025 |
| CITIGROUP INC | History | Reduced | 1 | 0 | — | 0.0% | — | -512 | -99.81% | Q4 2025 | Feb 13, 2026 |
| Rise Advisors, LLC | History | Closed out | 0 | 0 | — | — | — | -131 | -100.0% | Q3 2025 | Oct 08, 2025 |
| Fortitude Family Office, LLC | History | Closed out | 0 | 0 | — | — | — | -81 | -100.0% | Q3 2025 | Oct 17, 2025 |
| Allworth Financial LP | History | New | 26 | 0 | — | — | — | +26 | New | Q4 2025 | Feb 05, 2026 |
| Bruce G. Allen Investments, LLC | History | Closed out | 0 | 0 | — | — | — | -22 | -100.0% | Q3 2025 | Oct 30, 2025 |
| Advisory Services Network, LLC | History | Closed out | 0 | 0 | — | — | — | -12 | -100.0% | Q3 2025 | Nov 18, 2025 |
| PITTENGER & ANDERSON INC | History | Closed out | 0 | 0 | — | — | — | -3 | -100.0% | Q3 2025 | Nov 03, 2025 |
| HARBOUR INVESTMENTS, INC. | History | No change | 85 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 09, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | No change | 82 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 10, 2026 |
| CIBC Private Wealth Group LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 12, 2026 |
| West Branch Capital LLC | History | No change | 3 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Jan 16, 2026 |
| SBI Securities Co., Ltd. | History | No change | 74 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Feb 03, 2026 |
| Activest Wealth Management | History | No change | 66 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Jan 30, 2026 |
| MB, LEVIS & ASSOCIATES, LLC | History | No change | 100 | 0 | — | — | — | 0 | 0.0% | Q4 2025 | Jan 14, 2026 |