SPRUCE BIOSCIENCES, INC. - SPRB
Detailed investor-level table based on 13F positions.
Methodology:
Market value and % of portfolio use SEC reported VALUE ($000).
For PUT/CALL positions this reflects reported underlying exposure, not premium cash paid/received.
Details.
Rows: 0
| Investor | History | Status | Shares held | Market value ($000) | % of portfolio | Previous % | Rank | Change in shares | % change in shares | Source | Date reported |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AIGH Capital Management LLC | History | No change | 250,000 | 12,145 | 1.22% | 0.85% | 1 | 0 | 0.0% | Q3 2026 | Nov 02, 2026 |
| ORBIMED ADVISORS LLC | History | No change | 200,000 | 10,800 | 0.2% | 0.2% | 2 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BlackRock, Inc. | History | No change | 187,836 | 10,143 | 0.0% | 0.0% | 3 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| MILLENNIUM MANAGEMENT LLC | History | No change | 160,981 | 8,692 | 0.0% | 0.0% | 4 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Ikarian Capital, LLC | History | No change | 121,356 | 6,553 | 0.71% | 0.71% | 5 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | History | No change | 119,331 | 6,443 | 0.0% | 0.0% | 6 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Alyeska Investment Group, L.P. | History | No change | 81,671 | 4,410 | 0.01% | 0.01% | 7 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | History | No change | 70,548 | 3,809 | 0.0% | 0.0% | 8 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| ADAR1 Capital Management, LLC | History | No change | 67,717 | 3,656 | 0.17% | 0.17% | 9 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Cable Car Capital, LP | History | No change | 60,000 | 3,240 | 0.07% | 0.07% | 10 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITADEL ADVISORS LLC | History | No change | 51,905 | 2,802 | 0.0% | 0.0% | 11 | 0 | 0.0% | Q2 2026 | Sep 02, 2026 |
| STATE STREET CORP | History | No change | 50,450 | 2,724 | 0.0% | 0.0% | 12 | 0 | 0.0% | Q2 2026 | Sep 22, 2026 |
| BOOTHBAY FUND MANAGEMENT, LLC | History | No change | 42,080 | 2,272 | 0.03% | 0.03% | 13 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| STEMPOINT CAPITAL LP | History | No change | 41,388 | 2,234 | 0.38% | 0.38% | 14 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Eversept Partners, LP | History | No change | 40,000 | 2,160 | 0.11% | 0.11% | 15 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Carlyle Group Inc. | History | No change | 38,620 | 2,085 | 0.02% | 0.02% | 16 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| GOLDMAN SACHS GROUP INC | History | No change | 32,348 | 1,746 | 0.0% | 0.0% | 17 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Affinity Asset Advisors, LLC | History | No change | 30,000 | 1,620 | 0.07% | 0.07% | 18 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| DIADEMA PARTNERS LP | History | No change | 30,000 | 1,620 | 0.2% | 0.2% | 19 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Stonepine Capital Management, LLC | History | No change | 28,795 | 1,554 | 0.88% | 0.88% | 20 | 0 | 0.0% | Q2 2026 | Aug 17, 2026 |
| Point72 Asset Management, L.P. | History | No change | 28,278 | 1,527 | 0.0% | 0.0% | 21 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Quinn Opportunity Partners LLC | History | No change | 26,810 | 1,447 | 0.07% | 0.07% | 22 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| UBS Group AG | History | No change | 23,381 | 1,262 | 0.0% | 0.0% | 23 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| ExodusPoint Capital Management, LP | History | No change | 22,000 | 1,188 | 0.01% | 0.01% | 24 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NORTHERN TRUST CORP | History | No change | 21,083 | 1,138 | 0.0% | 0.0% | 25 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Rosalind Advisors, Inc. | History | No change | 20,000 | 1,080 | 0.4% | 0.4% | 26 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Knott David M Jr | History | No change | 20,000 | 1,080 | 0.57% | 0.57% | 27 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| AMERIPRISE FINANCIAL INC | History | No change | 18,834 | 1,017 | 0.0% | 0.0% | 28 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | History | No change | 18,496 | 998 | 0.0% | 0.0% | 29 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| VANGUARD FIDUCIARY TRUST CO | History | No change | 18,361 | 991 | 0.0% | 0.0% | 30 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| BALYASNY ASSET MANAGEMENT L.P. | History | No change | 12,138 | 655 | 0.0% | 0.0% | 31 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| DIMENSIONAL FUND ADVISORS LP | History | Reduced | 8,788 | 426 | 0.0% | 0.0% | 32 | -25 | -0.28% | Q3 2026 | Nov 04, 2026 |
| Persistent Asset Partners Ltd | History | No change | 7,677 | 414 | 0.12% | 0.12% | 33 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | History | No change | 7,182 | 387 | 0.0% | 0.0% | 34 | 0 | 0.0% | Q2 2026 | Aug 10, 2026 |
| Bank of New York Mellon Corp | History | Added to | 6,819 | 331 | 0.0% | 0.0% | 35 | +40 | 0.59% | Q3 2026 | Nov 05, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | History | No change | 5,896 | 318 | 0.0% | 0.0% | 36 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| RENAISSANCE TECHNOLOGIES LLC | History | No change | 4,700 | 253 | 0.0% | 0.0% | 37 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| MORGAN STANLEY | History | No change | 4,411 | 238 | 0.0% | 0.0% | 38 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Pale Fire Capital SE | History | No change | 3,818 | 206 | 0.01% | 0.01% | 39 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| RHUMBLINE ADVISERS | History | No change | 3,519 | 190 | 0.0% | 0.0% | 40 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| SkyView Investment Advisors, LLC | History | No change | 3,000 | 162 | 0.13% | 0.13% | 41 | 0 | 0.0% | Q2 2026 | Sep 14, 2026 |
| DEUTSCHE BANK AG\ | History | No change | 2,652 | 143 | 0.0% | 0.0% | 42 | 0 | 0.0% | Q2 2026 | Aug 07, 2026 |
| WELLS FARGO & COMPANY/MN | History | No change | 2,329 | 125 | 0.0% | 0.0% | 43 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| NEW YORK STATE COMMON RETIREMENT FUND | History | No change | 1,900 | 102 | 0.0% | 0.0% | 44 | 0 | 0.0% | Q2 2026 | Jul 29, 2026 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | History | No change | 1,252 | 67 | 0.0% | 0.0% | 45 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| JPMORGAN CHASE & CO | History | No change | 1,127 | 62 | 0.0% | 0.0% | 46 | 0 | 0.0% | Q2 2026 | Aug 12, 2026 |
| Lion Point Capital, LP | History | No change | 1,000 | 54 | 0.26% | 0.26% | 47 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Police & Firemen's Retirement System of New Jersey | History | No change | 864 | 46 | 0.0% | 0.0% | 48 | 0 | 0.0% | Q2 2026 | Jul 23, 2026 |
| BARCLAYS PLC | History | No change | 674 | 36 | 0.0% | 0.0% | 49 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| BNP PARIBAS FINANCIAL MARKETS | History | No change | 453 | 24 | 0.0% | 0.0% | 50 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Vanguard Global Advisers, LLC | History | No change | 452 | 24 | 0.0% | 0.0% | 51 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| FMR LLC | History | No change | 343 | 18 | 0.0% | 0.0% | 52 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Legal & General Group Plc | History | No change | 264 | 14 | 0.0% | 0.0% | 53 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| Ameritas Investment Partners, Inc. | History | No change | 247 | 13 | 0.0% | 0.0% | 54 | 0 | 0.0% | Q2 2026 | Aug 13, 2026 |
| Tower Research Capital LLC (TRC) | History | No change | 246 | 13 | 0.0% | 0.0% | 55 | 0 | 0.0% | Q2 2026 | Aug 11, 2026 |
| Russell Investments Group, Ltd. | History | No change | 217 | 11 | 0.0% | 0.0% | 56 | 0 | 0.0% | Q2 2026 | Aug 06, 2026 |
| SBI Securities Co., Ltd. | History | No change | 201 | 9 | 0.0% | 0.0% | 57 | 0 | 0.0% | Q3 2026 | Oct 21, 2026 |
| Pinnacle Wealth Planning Services, Inc. | History | New | 167 | 8 | 0.0% | — | 59 | +167 | New | Q3 2026 | Oct 27, 2026 |
| ROYAL BANK OF CANADA | History | No change | 166 | 8 | 0.0% | 0.0% | 58 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| CITIGROUP INC | History | Reduced | 122 | 5 | 0.0% | 0.0% | 60 | -1,143 | -90.36% | Q3 2026 | Nov 04, 2026 |
| Parkside Financial Bank & Trust | History | New | 97 | 4 | 0.0% | — | 61 | +97 | New | Q3 2026 | Oct 27, 2026 |
| GAMMA Investing LLC | History | New | 85 | 4 | 0.0% | — | 62 | +85 | New | Q3 2026 | Oct 08, 2026 |
| Sterling Capital Management LLC | History | Added to | 59 | 2 | 0.0% | 0.0% | 63 | +16 | 37.21% | Q3 2026 | Oct 22, 2026 |
| JONES FINANCIAL COMPANIES LLLP | History | No change | 30 | 1 | 0.0% | 0.0% | 64 | 0 | 0.0% | Q2 2026 | Aug 14, 2026 |
| SJS Investment Consulting Inc. | History | New | 17 | 0 | — | — | — | +17 | New | Q3 2026 | Oct 26, 2026 |
| Root Financial Partners, LLC | History | New | 8 | 0 | — | — | — | +8 | New | Q3 2026 | Oct 21, 2026 |
| Friedenthal Financial | History | Closed out | 0 | 0 | — | — | — | -7 | -100.0% | Q3 2026 | Oct 27, 2026 |
| Farther Finance Advisors, LLC | History | New | 1 | 0 | — | — | — | +1 | New | Q3 2026 | Oct 08, 2026 |
| CALDWELL SUTTER CAPITAL, INC. | History | No change | 13 | 0 | — | — | — | 0 | 0.0% | Q2 2026 | Aug 05, 2026 |
| Cassaday & Co Wealth Management LLC | History | No change | 2 | 0 | — | — | — | 0 | 0.0% | Q3 2026 | Oct 27, 2026 |