Casdin Capital, LLC

Q3 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
32
Total value ($000)
$1,199,325
Net value change ($000)
+101,167 (9.2%)
New positions
5
Sold out positions
6
Turnover %
13.1%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
RNAM 27,145 53.8%
TEM 23,739 NEW
RLAY 19,763 50.1%
GPCR 18,133 71.4%
RVMD 17,383 16.4%
SPRY 16,080 NEW
BEAM 14,167 57.4%
PRME 13,675 353.3%
MAZE 10,366 111.3%
LAB 9,536 10.4%
Top Reduces (Value $000, Stocks/ETFs)
Verve Therapeutics, Inc. -45,993 -100.0%
CDXS -17,568 -100.0%
SRPT -16,931 -100.0%
ILMN -11,680 -19.0%
LLY -6,626 -100.0%
SNDX -6,084 -100.0%
AGIO -3,326 -100.0%
ALNY -1,496 -5.6%
IPSC -74 -10.8%
RXRX -30 -3.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type