Casdin Capital, LLC

Q4 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
38
Total value ($000)
$1,609,916
Net value change ($000)
+410,591 (34.2%)
New positions
7
Sold out positions
1
Turnover %
5.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
RVMD 81,655 66.0%
WGS 67,120 20.7%
RLAY 50,808 85.8%
GPCR 38,181 87.7%
GH 32,565 521.2%
ILMN 28,837 57.8%
TXG 22,834 NEW
DNLI 17,455 135.1%
LAB 12,816 12.7%
MAZE 11,762 59.8%
Top Reduces (Value $000, Stocks/ETFs)
BLFS -27,056 -15.8%
PRME -6,556 -37.4%
TEM -6,371 -26.8%
RNAM -5,425 -7.0%
EXAS -4,924 -100.0%
HIMS -545 -4.2%
TNYA -328 -56.0%
DNA -229 -43.0%
RXRX -131 -16.2%
CTNM -48 -2.8%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type