BAKER BROS. ADVISORS LP

Q4 2020 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2020
Date filed
2/16/2021
Form type
13F-HR
Num holdings
126
Total value ($000)
$26,543,637
Net value change ($000)
+1,517,709 (6.1%)
New positions
15
Sold out positions
8
Turnover %
5.0%
Sector allocation + QoQ delta (equities-only)

Snapshot: Change Analysis

Compared to Q3 2020
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
KOD 1,307,732 178.8%
ACAD 511,655 29.6%
ABCL 420,515 NEW
PRLD 419,113 137.5%
ALXN 366,288 36.5%
Invitae Corp 140,553 27.4%
BMRN 88,112 15.3%
Mirati Therapeutics, Inc. 75,550 32.3%
RARE 61,524 NEW
KYMR 58,169 91.9%
Top Reduces (Value $000, Stocks/ETFs)
Seagen Inc. -971,387 -10.5%
ONC -794,983 -20.9%
MyoKardia, Inc. -410,264 -100.0%
EXAS -188,214 -100.0%
INCY -88,289 -3.1%
IMMUNOMEDICS INC -20,211 -100.0%
Forma Therapeutics Holdings, Inc. -17,624 -20.0%
ASMB -16,015 -63.2%
MDGL -11,334 -6.4%
Global Blood Therapeutics, Inc. -10,888 -21.5%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type