BAKER BROS. ADVISORS LP

Q4 2024 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2024
Date filed
2/14/2025
Form type
13F-HR
Num holdings
95
Total value ($000)
$9,361,492
Net value change ($000)
-287,266 (-3.0%)
New positions
9
Sold out positions
8
Turnover %
1.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2024 Next filing: 5/15/2025 SEC filing

Snapshot: Change Analysis

Compared to Q3 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
MDGL 190,252 45.4%
ACAD 127,348 19.3%
KOD 127,059 281.2%
INCY 91,326 4.5%
GRAL 29,098 NEW
CADL 25,884 NEW
INSM 23,312 7.2%
REPL 12,702 10.5%
ROIV 12,276 38.0%
CRSP 11,875 30.0%
Top Reduces (Value $000, Stocks/ETFs)
ONC -612,189 -25.8%
SMMT -99,043 -18.5%
BCYC -60,326 -28.4%
IGM Biosciences, Inc. -42,671 -63.0%
KYMR -42,571 -15.0%
DNLI -32,652 -30.0%
IMTX -21,788 -29.6%
RARE -21,246 -24.3%
BMEA -15,666 -73.5%
KNSA -14,684 -20.8%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type