RA CAPITAL MANAGEMENT, L.P.

Q4 2024 13F-HR Holdings

Location
Boston, MA
Holdings as of
12/31/2024
Date filed
2/14/2025
Form type
13F-HR
Num holdings
89
Total value ($000)
$7,514,204
Net value change ($000)
-1,159,375 (-13.4%)
New positions
17
Sold out positions
9
Turnover %
12.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2024 Next filing: 5/15/2025 SEC filing

Snapshot: Change Analysis

Compared to Q3 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
SEPN 160,205 NEW
JANX 138,581 33.3%
XBI 110,615 NEW
NAMS 93,455 69.8%
WAVE LIFE SCIENCES LTD 75,903 50.9%
ACLX 59,143 38.3%
TXG 47,092 NEW
KURA 38,769 NEW
ZLAB 33,917 NEW
VOR 28,083 176.4%
Top Reduces (Value $000, Stocks/ETFs)
PCVX -281,617 -28.4%
BIIB -229,595 -100.0%
EVH -200,557 -83.3%
LEGN -121,537 -33.2%
RNAM -106,162 -36.7%
CLYM -103,369 -64.6%
TYRA -97,036 -39.6%
DYN -78,871 -34.4%
RXST -64,924 -33.5%
VRNA -62,076 -43.1%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type