RA CAPITAL MANAGEMENT, L.P.

Q1 2025 13F-HR Holdings

Location
Boston, MA
Holdings as of
3/31/2025
Date filed
5/15/2025
Form type
13F-HR
Num holdings
85
Total value ($000)
$5,987,913
Net value change ($000)
-1,526,291 (-20.3%)
New positions
11
Sold out positions
15
Turnover %
17.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/14/2025 Next filing: 8/14/2025 SEC filing

Snapshot: Change Analysis

Compared to Q4 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ASND 210,253 15.1%
SION 109,258 NEW
IRON 78,288 NEW
MLYS 37,903 63.5%
SRRK 35,776 4701.2%
URGN 35,461 NEW
89bio, Inc. 33,746 30.4%
GHRS 29,792 63.6%
SPRY 22,048 19.2%
GKOS 18,725 NEW
Top Reduces (Value $000, Stocks/ETFs)
JANX -252,855 -45.6%
PCVX -251,035 -35.3%
LEGN -244,276 -100.0%
SEPN -119,699 -74.7%
XBI -110,615 -100.0%
AXSM -84,610 -100.0%
VRNA -82,052 -100.0%
WAVE LIFE SCIENCES LTD -78,087 -34.7%
ARTV -69,761 -70.2%
PRAX -58,640 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type