Sofinnova Investments, Inc.

Q3 2025 13F-HR Holdings

Location
Menlo Park, CA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
62
Total value ($000)
$1,828,831
Net value change ($000)
+193,812 (11.9%)
New positions
9
Sold out positions
9
Turnover %
15.3%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/13/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
VRTX 46,165 NEW
UTHR 45,857 134.7%
AZN 42,691 208.0%
AXSM 38,018 389.1%
RAPP 35,153 154.9%
GKOS 25,525 NEW
GILD 22,559 19.4%
RNAM 21,556 129.8%
APGE 19,156 579.1%
VERA 15,367 23.3%
Top Reduces (Value $000, Stocks/ETFs)
LLY -75,628 -100.0%
SLNO -23,546 -67.7%
IDYA -20,040 -44.4%
INOZYME PHARMA INC -17,121 -100.0%
REPL -16,783 -100.0%
INSM -16,567 -52.4%
ANAB -15,132 -66.0%
ABBV -14,392 -29.2%
SNDX -14,276 -100.0%
QURE -13,734 -63.2%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 198,680 (10.9% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type