Sofinnova Investments, Inc.

Q4 2025 13F-HR Holdings

Location
Menlo Park, CA
Holdings as of
12/31/2025
Date filed
2/13/2026
Form type
13F-HR
Num holdings
60
Total value ($000)
$2,319,284
Net value change ($000)
+490,453 (26.8%)
New positions
11
Sold out positions
6
Turnover %
22.0%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
NTRA 105,605 42.3%
AZN 86,848 137.4%
JAZZ 85,568 110.3%
BMY 81,611 NEW
LLY 66,256 NEW
VERA 60,295 74.3%
BMRN 41,431 NEW
COGT 39,546 129.4%
ABBV 37,655 107.7%
CDTX 34,629 667.2%
Top Reduces (Value $000, Stocks/ETFs)
GILD -139,007 -100.0%
BSX -55,593 -100.0%
AXSM -45,550 -95.3%
ROIV -31,708 -66.5%
DXCM -27,358 -52.2%
AKRO -22,488 -100.0%
Merus N.V. -15,698 -100.0%
PTCT -11,472 -100.0%
SLNO -10,666 -94.9%
EXAS -9,666 -48.4%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type