RA CAPITAL MANAGEMENT, L.P.

Q3 2025 13F-HR Holdings

Location
Boston, MA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
67
Total value ($000)
$8,115,527
Net value change ($000)
+2,179,846 (36.7%)
New positions
16
Sold out positions
12
Turnover %
9.1%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ASND 269,478 15.2%
RYTM 222,338 63.3%
MLYS 194,544 233.9%
RNAM 170,135 82.4%
CDTX 158,347 96.6%
SION 125,971 69.5%
NUVL 107,794 NEW
NAMS 104,735 57.0%
89bio, Inc. 97,061 49.7%
VOR 96,578 NEW
Top Reduces (Value $000, Stocks/ETFs)
DYN -92,481 -100.0%
SPRY -80,371 -42.4%
VOR -64,227 -100.0%
RXST -48,139 -100.0%
TRML -40,597 -100.0%
ELVN -17,031 -100.0%
HNGE -15,525 -100.0%
OMDA -7,320 -100.0%
BBNX -7,280 -100.0%
TXG -5,504 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type