Avoro Capital Advisors LLC
Q4 2025 13F-HR/A Holdings
Net value change ($000)
+2,437,875
(31.5%)
New positions
11
Sold out positions
8
Turnover %
20.4%
Sector allocation + QoQ delta (equities-only)
Snapshot: Change Analysis
Compared to Q3 2025
Methodology:
sector metrics are equities-only;
instrument mix chart is ex-options;
options exposure is shown separately.
Why this matters.
Top Adds (Value $000, Stocks/ETFs)
| UTHR | 422,067 | 49.8% |
| ARWR | 329,453 | 87.6% |
| GPCR | 311,583 | 215.8% |
| CELC | 310,302 | NEW |
| XBI | 256,053 | NEW |
| KYMR | 222,200 | 61.8% |
| KRYS | 221,865 | 45.2% |
| MDGL | 211,856 | 25.2% |
| TERN | 175,740 | NEW |
| RVMD | 172,841 | NEW |
Top Reduces (Value $000, Stocks/ETFs)
| Merus N.V. | -333,526 | -100.0% |
| AKRO | -187,810 | -100.0% |
| TRML | -122,232 | -100.0% |
| FOLD | -118,397 | -100.0% |
| QURE | -112,252 | -43.3% |
| 89bio, Inc. | -93,901 | -100.0% |
| SLNO | -39,988 | -22.9% |
| ALKERMES PLC | -28,028 | -41.7% |
| MLTX | -14,340 | -100.0% |
| BCRX | -9,488 | -100.0% |
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000):
625
(0.0% of total reported value)
How this table is calculated:
SEC
VALUE ($000) is used as reported.
For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received.
Column % is bucket-based:
non-options share is calculated inside non-option total, options share is calculated inside options total.
Details.
Filter:
Instrument:
| Issuer Name | Ticker | Sector | Industry | Class | History | Value ($000) | % | Shares | Shares Δ | Shares Δ% | Value Δ ($000) | Value Δ% | Principal | Option Type |
|---|