Redmile Group, LLC

Q4 2025 13F-HR Holdings

Location
San Francisco, CA
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
34
Total value ($000)
$1,357,911
Net value change ($000)
+330,095 (32.1%)
New positions
3
Sold out positions
9
Turnover %
7.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
NRIX 119,553 351.8%
SRRK 84,576 58.2%
IMNM 64,007 108.8%
KRYS 50,326 43.1%
ANNX 31,237 162.5%
STOK 29,916 30.5%
COGT 19,352 61.0%
RGNX 17,620 38.9%
NUVB 17,128 152.7%
RAPT 15,755 110.6%
Top Reduces (Value $000, Stocks/ETFs)
ZYME -50,349 -79.5%
LIVN -41,282 -85.0%
AKRO -35,506 -100.0%
89bio, Inc. -21,655 -100.0%
KROS -8,741 -100.0%
ADCT -7,363 -11.7%
FOLD -6,124 -100.0%
XERS -3,672 -100.0%
FATE -3,571 -22.0%
VTYX -3,338 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type