Sofinnova Investments, Inc.

Q1 2026 13F-HR Holdings

Location
Menlo Park, CA
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
74
Total value ($000)
$2,631,154
Net value change ($000)
+311,870 (13.4%)
New positions
17
Sold out positions
16
Turnover %
45.0%
Sector allocation + QoQ delta (equities-only)
Prev filing: 2/13/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
AZN 89,938 NEW
RARE 63,990 3339.8%
BIIB 42,078 NEW
BMY 39,005 47.8%
AXSM 33,718 1505.3%
INSM 29,300 107.4%
ALC 28,797 109.9%
SUPN 21,839 79.4%
GMAB 20,183 NEW
NKTR 18,117 97.7%
Top Reduces (Value $000, Stocks/ETFs)
AZN -150,060 -100.0%
VRTX -74,620 -100.0%
ABBV -72,610 -100.0%
ISRG -71,910 -100.0%
LLY -66,256 -100.0%
RNAM -53,745 -100.0%
JAZZ -50,062 -30.7%
NTRA -45,114 -12.7%
APGE -40,370 -100.0%
CDTX -39,819 -100.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 635,227 (24.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type