ORBIMED ADVISORS LLC

Q4 2024 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2024
Date filed
2/14/2025
Form type
13F-HR
Num holdings
118
Total value ($000)
$4,861,410
Net value change ($000)
-642,109 (-11.7%)
New positions
20
Sold out positions
18
Turnover %
16.6%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 11/14/2024 Next filing: 5/15/2025 SEC filing

Snapshot: Change Analysis

Compared to Q3 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
UPB 93,603 NEW
NBIX 93,231 267.7%
EW 84,787 NEW
CYTK 34,019 84.0%
XBI 33,502 NEW
ALNY 28,955 42.1%
IRON 25,462 29.0%
RAPT 20,754 NEW
FOLD 15,437 253.4%
CGON 14,968 57.4%
Top Reduces (Value $000, Stocks/ETFs)
QTTB -92,778 -92.3%
AMGN -81,294 -100.0%
BIIB -79,740 -50.6%
MRK -66,887 -44.8%
ELV -55,224 -100.0%
REGN -47,516 -100.0%
EVH -47,089 -100.0%
PCVX -44,222 -100.0%
KROS -43,031 -72.7%
LLY -38,466 -12.9%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 45,347 (0.9% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type