Upstream Bio, Inc. - UPB
Sector:
Healthcare
· Industry:
Pharmaceutical Preparations
Website:
No information yet
· Social:
No information yet
Company profile
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Quarter snapshot
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Q4 2025
· Q3 2025
Value (USD)
Total reported value ($000)
$1.391B
QoQ value delta ($000)
+$547.3M
(+64.84%)
Implied price effect (QoQ)
+44.33%
Shares
Total shares
51,253,921
QoQ shares delta
+6,377,493
(+14.21%)
Total shares held by funds (by quarter)
Market chart (UPB)
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Top holders (Q4 2025)
Top 25 only
Full list
| Manager | Value ($000) | Shares | % of 13F |
|---|---|---|---|
| FMR LLC | 204,119 | 7,518,202 | 0.01% |
| ORBIMED ADVISORS LLC | 154,580 | 5,693,589 | 3.16% |
| BlackRock, Inc. | 90,803 | 3,344,504 | 0.0% |
| Decheng Capital LLC | 85,334 | 3,143,078 | 11.48% |
| NORGES BANK | 78,263 | 2,882,647 | 0.01% |
| Enavate Sciences GP, LLC | 66,780 | 2,459,703 | 13.18% |
| VANGUARD GROUP INC | 64,846 | 2,388,439 | 0.0% |
| UBS Group AG | 49,039 | 1,806,243 | 0.01% |
| JANUS HENDERSON GROUP PLC | 41,422 | 1,527,958 | 0.02% |
| Altshuler Shaham Ltd | 36,422 | 1,341,540 | 0.55% |
| Bain Capital Life Sciences Investors, LLC | 36,097 | 1,329,544 | 2.76% |
| Omega Fund Management, LLC | 36,008 | 1,326,293 | 12.57% |
| STATE STREET CORP | 35,816 | 1,319,226 | 0.0% |
| VR Adviser, LLC | 31,746 | 1,169,298 | 1.57% |
| WELLINGTON MANAGEMENT GROUP LLP | 24,292 | 894,733 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 23,134 | 851,908 | 0.0% |
| Parkman Healthcare Partners LLC | 22,658 | 834,559 | 2.16% |
| Pictet Asset Management Holding SA | 20,990 | 773,148 | 0.02% |
| Woodline Partners LP | 20,640 | 760,252 | 0.08% |
| Integral Health Asset Management, LLC | 20,362 | 750,000 | 1.01% |
| TCG Crossover Management, LLC | 20,196 | 743,886 | 0.67% |
| Samsara BioCapital, LLC | 19,983 | 736,047 | 2.06% |
| Vestal Point Capital, LP | 19,548 | 720,000 | 0.66% |
| Siren, L.L.C. | 15,976 | 588,450 | 0.48% |
| BARCLAYS PLC | 14,240 | 524,499 | 0.0% |