Upstream Bio, Inc. - UPB

Sector: Healthcare · Industry: Pharmaceutical Preparations

Website: No information yet · Social: No information yet

Company profile

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Q1 2026 · Q4 2025

Value (USD)

Total reported value ($000)

$548.8M

QoQ value delta ($000)

-$842.6M (-60.56%)

Implied price effect (QoQ)

-59.81%

Total shares

50,305,801

QoQ shares delta

-948,120 (-1.85%)

Total shares held by funds (by quarter)

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Top 25 only Full list

Partial Q1 2026 data: 141 holders have filed so far. Prior holders are carried forward until their next 13F confirms a change.

Manager	Value ($000)	Shares	% of 13F
NORGES BANK	78,263	2,882,647	0.01%
FMR LLC	72,914	8,101,563	0.0%
VANGUARD GROUP INC	64,846	2,388,439	0.0%
ORBIMED ADVISORS LLC	51,242	5,693,589	1.02%
BlackRock, Inc.	30,336	3,370,689	0.0%
Decheng Capital LLC	24,523	2,724,868	3.71%
Enavate Sciences GP, LLC	22,137	2,459,703	6.3%
VANGUARD CAPITAL MANAGEMENT LLC	16,862	1,873,574	0.0%
Y-Intercept (Hong Kong) Ltd	9,005	1,000,631	0.17%
FEDERATED HERMES, INC.	8,817	979,758	0.01%
GEODE CAPITAL MANAGEMENT, LLC	8,557	950,617	0.0%
MILLENNIUM MANAGEMENT LLC	8,435	937,323	0.0%
SEB Asset Management AB	7,906	878,473	0.03%
Bain Capital Life Sciences Investors, LLC	7,804	867,211	0.7%
Woodline Partners LP	7,483	831,481	0.03%
D. E. Shaw & Co., Inc.	7,384	820,480	0.0%
Parkman Healthcare Partners LLC	7,081	786,783	0.73%
Samsara BioCapital, LLC	6,624	736,047	0.64%
Pictet Asset Management Holding SA	6,600	733,431	0.01%
VANGUARD PORTFOLIO MANAGEMENT LLC	6,549	727,711	0.0%
STATE STREET CORP	6,348	705,350	0.0%
HSBC HOLDINGS PLC	5,762	640,326	0.0%
Qube Research & Technologies Ltd	5,573	619,321	0.01%
MORGAN STANLEY	4,973	552,609	0.0%
JPMORGAN CHASE & CO	4,065	463,001	0.0%