ORBIMED ADVISORS LLC

Q1 2025 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
3/31/2025
Date filed
5/15/2025
Form type
13F-HR
Num holdings
111
Total value ($000)
$4,194,646
Net value change ($000)
-666,764 (-13.7%)
New positions
11
Sold out positions
16
Turnover %
17.4%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q4 2024
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
PFE 97,564 NEW
AXSM 45,101 NEW
UNH 39,162 59.1%
SION 38,754 NEW
TARS 33,583 NEW
APLS 31,324 NEW
EW 26,252 31.0%
RNAM 21,153 65.4%
TMO 20,283 46.2%
CGON 19,495 47.5%
Top Reduces (Value $000, Stocks/ETFs)
SRPT -117,140 -100.0%
MRK -82,558 -100.0%
BIIB -77,852 -100.0%
EWTX -70,602 -17.6%
ISRG -65,547 -31.3%
UPB -58,758 -62.8%
UHS -48,318 -100.0%
IRON -42,963 -38.0%
MBX -40,718 -58.0%
Third Harmonic Bio, Inc. -39,414 -66.3%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 30,994 (0.7% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 ORBIMED CAPITAL LLC 028-10410