HighVista Strategies LLC

Q4 2025 13F-HR Detailed Holdings

Location
Boston, MA
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
145
Total value ($000)
$388,309
Net value change ($000)
-19,657 (-4.8%)
New positions
33
Sold out positions
36
Turnover %
34.8%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

Prev filing: 11/14/2025 Next filing: — SEC filing
You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
TERN 7,089 NEW
MAZE 7,058 NEW
GPCR 6,808 102.9%
COGT 5,318 80.1%
SLNO 4,990 394.8%
PHVS 4,506 NEW
STOK 3,667 NEW
CMPS 3,443 NEW
RLAY 3,356 267.4%
LBRX 3,119 NEW
Top Reduces (Value $000, Stocks/ETFs)
Merus N.V. -12,552 -100.0%
DBC -8,716 -26.9%
ABVX -5,926 -37.8%
AKRO -5,227 -100.0%
SNDK -4,285 -80.5%
ELVN -4,033 -76.0%
AGIO -3,820 -48.7%
MLYS -3,437 -43.2%
XENE -3,300 -100.0%
ACLX -3,006 -38.1%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 HighVista Private Capital Management LLC