HighVista Strategies LLC

Q4 2025 13F-HR Holdings

Location
Boston, MA
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
145
Total value ($000)
$388,309
Net value change ($000)
-19,657 (-4.8%)
New positions
33
Sold out positions
36
Turnover %
34.8%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
TERN 7,089 NEW
MAZE 7,058 NEW
GPCR 6,808 102.9%
COGT 5,318 80.1%
SLNO 4,990 394.8%
PHVS 4,506 NEW
STOK 3,667 NEW
CMPS 3,443 NEW
RLAY 3,356 267.4%
LBRX 3,119 NEW
Top Reduces (Value $000, Stocks/ETFs)
Merus N.V. -12,552 -100.0%
DBC -8,716 -26.9%
ABVX -5,926 -37.8%
AKRO -5,227 -100.0%
SNDK -4,285 -80.5%
ELVN -4,033 -76.0%
AGIO -3,820 -48.7%
MLYS -3,437 -43.2%
XENE -3,300 -100.0%
ACLX -3,006 -38.1%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type