HighVista Strategies LLC

Q1 2026 13F-HR Holdings

Location
Boston, MA
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
156
Total value ($000)
$362,159
Net value change ($000)
-26,150 (-6.7%)
New positions
35
Sold out positions
24
Turnover %
28.3%
Sector allocation + QoQ delta (equities-only)

Holdings aggregated across other managers listed in the original SEC filing. View detailed breakdown

Prev filing: 2/17/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
DBC 6,967 29.5%
TYRA 4,107 445.4%
ORKA 3,871 NEW
MLTX 3,615 NEW
DFTX 3,513 NEW
NRIX 3,511 NEW
IVA 3,417 NEW
ERAS 2,930 NEW
ABVX 2,876 29.5%
XENE 2,852 NEW
Top Reduces (Value $000, Stocks/ETFs)
VRDN -8,965 -77.3%
GPCR -7,451 -55.5%
CDTX -5,065 -100.0%
ACLX -4,890 -100.0%
COGT -4,374 -36.6%
OLMA -4,284 -71.0%
MAZE -4,077 -57.8%
AGIO -4,019 -100.0%
APLS -3,787 -100.0%
APGE -3,725 -55.3%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type