ORBIMED ADVISORS LLC

Q2 2026 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
6/30/2026
Date filed
8/14/2026
Form type
13F-HR
Num holdings
129
Total value ($000)
$5,396,780
Net value change ($000)
+351,416 (7.0%)
New positions
32
Sold out positions
21
Turnover %
17.9%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
EWTX 141,684 29.0%
LLY 91,531 42.0%
MBX 80,675 74.3%
UNH 66,958 NEW
Ascendis Pharma AS 65,201 NEW
HUM 65,184 NEW
ODYSSEY THERAPEUTICS INC 56,152 NEW
ARQT 53,541 NEW
COGT 52,668 424.8%
QURE 48,327 138.4%
Top Reduces (Value $000, Stocks/ETFs)
MYGN -122,875 -100.0%
BSX -86,174 -57.7%
PFE -54,658 -100.0%
DHR -50,396 -100.0%
CMPX -47,182 -58.6%
IRON -42,109 -61.7%
ASND -41,624 -100.0%
ALNY -34,256 -87.0%
ISRG -33,415 -34.7%
SION -29,113 -20.6%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 117,379 (2.2% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 ORBIMED CAPITAL LLC 028-10410