ORBIMED ADVISORS LLC

Q1 2026 13F-HR Detailed Holdings

Location
New York, NY
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
114
Total value ($000)
$5,045,364
Net value change ($000)
+145,972 (3.0%)
New positions
23
Sold out positions
21
Turnover %
25.8%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ELVN 189,437 154.5%
AZN 132,177 NEW
MYGN 122,875 NEW
EWTX 103,741 26.9%
MRK 79,800 NEW
CRVS 49,653 90.0%
XENE 41,593 207.5%
GH 40,199 NEW
PRAX 27,725 99.5%
SNDX 22,479 NEW
Top Reduces (Value $000, Stocks/ETFs)
LLY -105,892 -32.7%
UPB -103,339 -66.9%
TERN -86,993 -100.0%
BSX -81,203 -35.2%
ALNY -75,467 -65.7%
APLS -61,038 -100.0%
EW -58,561 -37.3%
CI -56,422 -100.0%
RAPT -55,645 -100.0%
SYK -54,260 -47.5%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 459,937 (9.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 ORBIMED CAPITAL LLC 028-10410