Sio Capital Management, LLC

Q3 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
9/30/2025
Date filed
11/13/2025
Form type
13F-HR
Num holdings
51
Total value ($000)
$395,155
Net value change ($000)
+133,316 (50.9%)
New positions
15
Sold out positions
13
Turnover %
52.8%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/13/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CELC 38,854 NEW
ALKERMES PLC 20,245 NEW
DNTH 18,336 416.9%
SNY 17,502 193.2%
HSIC 14,549 NEW
KVUE 13,698 NEW
MMS 12,473 32.4%
GSK 11,605 NEW
HAE 9,652 NEW
KALV 8,329 NEW
Top Reduces (Value $000, Stocks/ETFs)
GMED -14,494 -100.0%
NBIX -12,660 -100.0%
ANNX -9,830 -100.0%
AORT -4,937 -100.0%
AVNS -3,536 -100.0%
Merus N.V. -3,299 -100.0%
MBX -2,750 -100.0%
SEPN -2,618 -42.4%
ANIP -2,264 -30.7%
EWTX -2,094 -29.6%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type