Sio Capital Management, LLC

Q4 2025 13F-HR Holdings

Location
New York, NY
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
68
Total value ($000)
$635,740
Net value change ($000)
+240,585 (60.9%)
New positions
24
Sold out positions
10
Turnover %
56.3%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/13/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CI 47,395 NEW
ZBH 34,677 NEW
OGN 24,534 NEW
ICLR 23,179 NEW
SNY 20,528 77.3%
WAY 20,099 NEW
LIVN 19,836 NEW
BHVN 14,053 NEW
GPCR 14,014 NEW
KVUE 11,581 84.5%
Top Reduces (Value $000, Stocks/ETFs)
ALKERMES PLC -17,577 -86.8%
MRK -14,881 -100.0%
HSIC -14,549 -100.0%
IRON -14,246 -75.7%
GSK -11,605 -100.0%
KALV -8,329 -100.0%
MMS -7,763 -15.2%
NVCR -5,347 -100.0%
DRUG -5,182 -44.8%
SLP -4,827 -100.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 32,582 (5.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type