Opaleye Management Inc.

Q1 2026 13F-HR Holdings

Location
Boston, MA
Holdings as of
3/31/2026
Date filed
5/15/2026
Form type
13F-HR
Num holdings
54
Total value ($000)
$759,221
Net value change ($000)
+1,327 (0.2%)
New positions
9
Sold out positions
10
Turnover %
8.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 4/13/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q4 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
ETON 22,222 45.9%
SLGL 20,489 107.2%
URGN 19,425 309.0%
MGTX 15,280 491.8%
CATX 14,505 290.7%
IRON 11,037 69.5%
CBIO 10,138 72.5%
QTTB 7,357 1039.1%
ALMS 6,895 132.0%
ASRT 5,064 NEW
Top Reduces (Value $000, Stocks/ETFs)
HROW -91,481 -47.8%
OCUL -14,281 -73.8%
ALKERMES PLC -13,710 -100.0%
SNWV -12,315 -42.1%
CGON -10,607 -62.3%
GOSS -8,432 -100.0%
KPTI -6,845 -100.0%
PLX -3,723 -83.5%
DERM -3,015 -40.1%
ZYME -2,868 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type