Opaleye Management Inc.

Q4 2025 13F-HR/A Holdings

Location
Boston, MA
Holdings as of
12/31/2025
Date filed
4/13/2026
Form type
13F-HR/A - RESTATEMENT
Num holdings
54
Total value ($000)
$757,894
Net value change ($000)
+50,573 (7.1%)
New positions
21
Sold out positions
9
Turnover %
20.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
LQDA 25,517 42.9%
APGE 14,874 103.1%
CBIO 13,975 NEW
SLGL 13,150 220.2%
ACOG 12,710 1694.7%
KPTI 6,845 NEW
JBIO 6,598 NEW
RZLT 6,346 74.7%
URGN 6,286 NEW
STOK 6,032 37.6%
Top Reduces (Value $000, Stocks/ETFs)
IMNM -37,296 -100.0%
CDXS -20,153 -64.6%
ETON -13,785 -22.2%
RYTM -11,304 -24.2%
SRPT -11,273 -100.0%
LRMR -10,565 -100.0%
ARVN -8,416 -100.0%
SNWV -7,449 -20.3%
TMCI -4,712 -100.0%
TGTX -3,379 -17.5%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type