Opaleye Management Inc.

Q2 2026 13F-HR Holdings

Location
Boston, MA
Holdings as of
6/30/2026
Date filed
8/14/2026
Form type
13F-HR
Num holdings
58
Total value ($000)
$1,104,182
Net value change ($000)
+344,961 (45.4%)
New positions
13
Sold out positions
8
Turnover %
10.2%
Sector allocation + QoQ delta (equities-only)
Prev filing: 5/15/2026 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
LQDA 106,318 119.7%
IRON 35,616 132.3%
ETON 32,947 46.7%
MGTX 29,574 160.8%
URGN 27,281 106.1%
IMMX 24,177 NEW
APGE 18,939 57.7%
GLUE 18,029 NEW
REPL 15,332 NEW
RZLT 13,545 70.5%
Top Reduces (Value $000, Stocks/ETFs)
RYTM -21,722 -61.5%
CATX -19,495 -100.0%
SNWV -13,905 -82.0%
CGON -5,152 -80.3%
ASRT -5,064 -100.0%
STRO -4,750 -100.0%
TECX -3,802 -100.0%
ANNX -3,128 -24.2%
JBIO -2,786 -46.4%
SLGL -2,540 -6.4%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type