SPHERA FUNDS MANAGEMENT LTD.

Q3 2025 13F-HR Detailed Holdings

Location
Tel Aviv, L3
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
115
Total value ($000)
$474,069
Net value change ($000)
+47,929 (11.2%)
New positions
23
Sold out positions
23
Turnover %
31.1%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
NICE 22,788 NEW
QQQ 13,784 NEW
TSEM 11,067 96.4%
RARE 6,966 191.4%
CLBT 5,540 NEW
RAPP 4,679 NEW
VRNS 4,247 NEW
MDWD 3,339 NEW
DYN 3,287 155.9%
TEVA 3,274 12.1%
Top Reduces (Value $000, Stocks/ETFs)
SNDX -8,753 -59.5%
NVDA -8,613 -100.0%
NVMI -6,838 -32.8%
MSFT -5,865 -100.0%
TVTX -4,963 -100.0%
AMZN -4,096 -57.6%
ORA -3,742 -57.3%
RNAM -3,578 -100.0%
META -3,411 -54.2%
AMAT -3,295 -100.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 52,469 (11.1% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 Sphera Global Healthcare Management LP 028-15865
2 Sphera Global Healthcare GP Ltd. 028-15864