SPHERA FUNDS MANAGEMENT LTD.

Q2 2026 13F-HR Detailed Holdings

Location
Tel Aviv, L3
Holdings as of
6/30/2026
Date filed
8/14/2026
Form type
13F-HR
Num holdings
106
Total value ($000)
$766,540
Net value change ($000)
+136,857 (21.7%)
New positions
22
Sold out positions
17
Turnover %
26.4%
Sector allocation + QoQ delta (equities-only)

Holdings broken out by other managers reported in the original SEC filing. View aggregated holdings

You are on the SEC detailed breakdown page. Rows are shown as reported in the filing (including other manager, discretion, and voting authority fields), and are not merged like the standard holdings view. Switch to aggregated holdings.

Snapshot: Change Analysis

Compared to Q1 2026
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
TEVA 16,577 48.4%
CYTK 16,117 614.2%
INSM 12,666 NEW
BMRN 10,897 137.9%
RYTM 8,927 NEW
LRCX 8,004 NEW
AMAT 7,982 NEW
IDYA 7,320 NEW
NVCT 7,042 NEW
HRMY 6,432 NEW
Top Reduces (Value $000, Stocks/ETFs)
NVMI -9,511 -41.0%
FOLD -8,725 -100.0%
CLBT -8,702 -100.0%
APLS -8,646 -100.0%
PANW -8,465 -100.0%
CAMT -8,038 -100.0%
SLNO -7,241 -100.0%
AMZN -6,652 -100.0%
AAOI -6,209 -100.0%
ENPH -5,385 -100.0%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 67,715 (8.8% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type Discretion Other Manager Sole Shared None

Other Managers

Num Name File Number
1 Sphera Global Healthcare Management LP 028-15865
2 Sphera Global Healthcare GP Ltd. 028-15864