Avidity Partners Management LP

Q4 2025 13F-HR Holdings

Location
Dallas, TX
Holdings as of
12/31/2025
Date filed
2/13/2026
Form type
13F-HR
Num holdings
39
Total value ($000)
$346,693
Net value change ($000)
-92,702 (-21.1%)
New positions
11
Sold out positions
15
Turnover %
30.4%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
JBIO 11,885 122.2%
ALNY 8,351 NEW
ORKA 7,317 57.6%
ICLR 6,031 NEW
A 5,647 NEW
RGEN 5,127 164.6%
CNC 4,913 NEW
NVO 3,424 NEW
MCK 3,328 74.3%
WAT 3,077 NEW
Top Reduces (Value $000, Stocks/ETFs)
DNTH -39,372 -31.2%
BMY -11,618 -100.0%
NTRA -8,629 -76.1%
MDT -7,817 -43.1%
Metsera, Inc. -7,352 -100.0%
DHR -6,953 -64.1%
UNH -6,146 -100.0%
ARVN -5,950 -100.0%
TMO -5,285 -57.7%
BSX -5,123 -31.9%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type