5AM Venture Management, LLC

Q3 2025 13F-HR Holdings

Location
San Francisco, CA
Holdings as of
9/30/2025
Date filed
11/14/2025
Form type
13F-HR
Num holdings
25
Total value ($000)
$273,045
Net value change ($000)
+12,925 (5.0%)
New positions
1
Sold out positions
5
Turnover %
12.5%
Sector allocation + QoQ delta (equities-only)
Prev filing: 8/14/2025 Next filing: 2/17/2026 SEC filing

Snapshot: Change Analysis

Compared to Q2 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CAMP 13,362 314.8%
PHVS 5,862 41.8%
VRDN 5,598 54.4%
CNTA 5,594 51.2%
EYPT 5,071 51.3%
ERAS 4,919 71.7%
TYRA 4,152 46.2%
ARTV 3,201 90.1%
CLDX 2,745 27.1%
PRAX 1,861 26.0%
Top Reduces (Value $000, Stocks/ETFs)
MLTX -13,325 -100.0%
VOR -10,306 -100.0%
VKTX -5,024 -100.0%
SCPH -4,574 -100.0%
TRDA -4,265 -14.7%
DNTH -3,980 -21.7%
SKYE -3,388 -8.2%
TECX -2,139 -21.0%
Mersana Therapeutics, Inc. -386 -100.0%
SLN -291 -10.5%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
Filter:
Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type