5AM Venture Management, LLC

Q4 2025 13F-HR Holdings

Location
San Francisco, CA
Holdings as of
12/31/2025
Date filed
2/17/2026
Form type
13F-HR
Num holdings
21
Total value ($000)
$318,103
Net value change ($000)
+45,058 (16.5%)
New positions
1
Sold out positions
5
Turnover %
14.4%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CAMP 18,371 104.3%
TRDA 17,013 68.9%
MPLT 16,687 NEW
TYRA 13,919 105.9%
ERAS 8,324 70.6%
VRDN 7,027 44.2%
SRZN 4,764 119.3%
TECX 4,627 57.6%
ZNTL 4,590 620.3%
EYPT 4,232 28.3%
Top Reduces (Value $000, Stocks/ETFs)
SKYE -30,791 -80.9%
DNTH -14,365 -100.0%
PRAX -9,010 -100.0%
ELVN -3,917 -24.8%
ALEC -2,948 -100.0%
ADVM -2,454 -100.0%
CNTA -1,984 -12.0%
GHRS -916 -11.2%
MRSN -405 -100.0%
Instrument mix + QoQ Δ (ex-options)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type