Soleus Capital Management, L.P.

Q4 2025 13F-HR Holdings

Location
Greenwich, CT
Holdings as of
12/31/2025
Date filed
2/12/2026
Form type
13F-HR
Num holdings
95
Total value ($000)
$2,710,906
Net value change ($000)
+724,459 (36.5%)
New positions
32
Sold out positions
25
Turnover %
28.6%
Sector allocation + QoQ delta (equities-only)
Prev filing: 11/14/2025 Next filing: — SEC filing

Snapshot: Change Analysis

Compared to Q3 2025
Methodology: sector metrics are equities-only; instrument mix chart is ex-options; options exposure is shown separately. Why this matters.
Top Adds (Value $000, Stocks/ETFs)
CELC 122,120 209.7%
DXCM 86,088 NEW
GMED 67,364 668.3%
PRAX 61,445 134.9%
KRYS 52,155 29.0%
PODD 42,636 NEW
FOLD 37,195 100.6%
ALKERMES PLC 37,000 NEW
LIVN 34,918 NEW
MIRM 34,409 315.6%
Top Reduces (Value $000, Stocks/ETFs)
ELV -83,898 -100.0%
TERN -52,442 -85.9%
TGTX -45,308 -32.6%
CDTX -38,714 -81.9%
UTHR -33,647 -53.5%
INDV -31,757 -89.8%
MDGL -31,052 -99.1%
INSP -26,418 -48.9%
GRFS -24,900 -100.0%
ARGX -24,526 -47.9%
Instrument mix + QoQ Δ (ex-options)
Derivatives reported exposure ($000): 353,597 (13.0% of total reported value)
How this table is calculated: SEC VALUE ($000) is used as reported. For derivatives (PUT/CALL/WARRANT/RIGHT), SEC value represents reported underlying exposure, not premium cash paid/received. Column % is bucket-based: non-options share is calculated inside non-option total, options share is calculated inside options total. Details.
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Instrument:
Issuer Name Ticker Sector Industry Class History Value ($000) % Shares Shares Δ Shares Δ% Value Δ ($000) Value Δ% Principal Option Type